Objective:To explore the clinical value of DTI in evaluating the disease severity in children with Duchenne muscular dystrophy(DMD).Methods:Twenty-eight children with DMD underwent conventional MRI and DTI of thigh muscles.The FA value and ADC value of 14 right thigh muscles(gluteus maximus,tensor fascia lata,lateral femoris,middle femoris,medial femoris,rectus femoris,sartorius,adductor longus,adductor major,gracilis,semimembranous,semitendinosus,biceps femoris long head and short head)were measured.The motor function of children was evaluated by using Motor Function Measure(MFM)scale.The correlation of FA and ADC value of each muscle,the average FA and ADC value of 14 muscles with the total MFM score was analyzed.Results:Except sartorius,gracilis,semimembranous and semitendinosus,FA values of the other muscles were negatively correlated with the total MFM score(all P<0.05),and ADC values were positively correlated with the total MFM score(all P<0.05).FA value of gluteus maximus had the highest correlation with the total MFM score(r=-0.587),and ADC value of lateral femoris had the highest correlation(r=0.470).The average FA value of 14 muscles was negatively correlated with the total MFM score(r=-0.539,P<0.05),and the average ADC value was positively correlated with the total MFM score(r=0.478,P<0.05).Conclusions:DTI can be used to quantify and objectively analyze the clinical severity of children with DMD.FA value of gluteus maximus has the highest correlation with the total MFM score,suggesting that FA value of gluteus maximus may be an ideal index to reflect the motor function of children with DMD.
Muscular dystrophyMagnetic resonance imagingMotor function assessment
国家科技期刊平台
NSTL
维普
万方数据
