Objective:To investigate the changes of brain nerve activity in primary insomnia patients with emotional disorders.Methods:Twenty primary insomnia patients(the insomnia group)and 20 healthy subjects(the control group)were recruited and subjected to resting-state fMRI.The amplitude of low-frequency fluctuation(ALFF)values were compared between the two groups and the correlations between ALFF values and the evaluation scales were analyzed.Results:The Pittsburgh sleep quality index(PSQI),self-rating anxiety scale(SAS),and self-rating depression scale(SDS)scores in the insomnia group were significantly different from those in the control group(all P＜0.05).Compared with the control group,the primary insomnia group showed increased ALFF values in the left inferior temporal gyrus,right orbitofrontal cortex,right anterior cingulate,right middle temporal gyrus,bilateral superior frontal gyrus,right superior occipital gyrus and left posterior central gyrus,and decreased ALFF values in the left middle cingulate,left middle frontal gyrus and right superior frontal gyrus(P＜0.01,AlphaSim corrected).Furthermore,the SDS scores were positive correled with ALFF values in the right orbitofrontal cortex and left cingulate gyrus(r=0.528,0.641,both P＜0.05),and the SAS score had a positive correlation with ALFF value in the left cingulate gyrus(r=0.494,P=0.037).Conclusions:The changes of brain nerve activity in primary insomnia patients with emotional disorders can be analyzed by ALFF,mainly the abnormal spontaneous brain activity in the brain regions related to emotion-cognition(cingulate gyrus,orbitofertal cortex,etc.),and the spontaneous brain activity in some brain regions is correlated with clinical indicators.Abnormal spontaneous activity could be an efficient neuroimaging biomarker for primary insomnia and could establish a foundation for the assessment of disease severity and treatment recommendations.
Primary insomniaMagnetic resonance imagingAmplitude of low-frequency fluctuation
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