Objective:To explore the relationship of the gray matter volume and the degree of cognitive impairment in patients with vascular cognitive impairment(VCI)by the voxel-based morphometry(VBM)method.Methods:A total of 157 VCI patients were divided into the mild,moderate and severe groups based on the score of Montreal Cognitive Assessment(MoCA).All patients underwent MRI scan and VBM analysis.Finally,the volumes of total intracranial,gray matter,white matter,ventricle/cerebrospinal fluid and the ratio of the gray/white matter volume to the total intracranial volume were compared among the three groups.The correlations between gray matter volumes of different brain regions and MoCA score were analyzed.Results:Compared with the mild group,the gray matter volumes in the right inferior temporal gyrus,right middle temporal gyrus,right middle frontal gyrus,right inferior frontal gyrus,right hippocampus,right supplementary motor area and left paracentral lobule were significantly lower in the severe group(all P＜0.05).There was a positive correlation between gray matter volume and MoCA score(r=0.249,P＜0.001).The gray matter volume in the right hippocampus was positively correlated with the MoCA score(r=0.432,P＜0.001).Conclusions:VCI patients with different levels of cognitive impairment have gray matter volume changes in the frontal lobe,temporal lobe,parietal lobe and hippocampus.From the perspective of gray matter volume differences,this study provides neuroimaging evidence supporting the classification to the degree of cognitive impairment.
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