Objective:To explore the effect of blood uric acid and calcification score to CT-based noninvasive fractional flow reserve(CT-FFR)in patients with chronic coronary syndrome(CCS).Methods:A total of 150 CCS patients were enrolled,all patients underwent coronary CTA(CCTA)and stenosis in the target vessels was detected.and the serum uric acid concentration was measured during hospitalization.CT-FFR was calculated by deep learning method,and the lowest value among the three target vessels was taken as the CT-FFR value.According to the CT-FFR value,all patients were divided into the normal group(CT-FFR＞0.8,77 cases)and the abnormal group(CT-FFR≤0.8,73 cases),and the serum uric acid and the total calcification score were compared between the two groups.Pearson correlation analysis was performed for CT-FFR and serum uric acid,total calcification score,logistic regression analysis was performed,and the diagnostic accuracy was analyzed by ROC curve.Results:There was a statistically significant difference in calcification score between the two groups(Z=-5.958,P＜0.05)and no significant difference in serum uric acid(t=-0.448,P＞0.05).Pearson correlation analysis revealed a significant negative correlation between calcification score and CT-FFR(r=-0.556,P＜0.05).The AUC was 0.782,and the calcification score threshold for pathological level(CT-FFR≤0.8)was 313.05 points,with a Youden index of 0.464,an accuracy of 78.2%,a sensitivity of 68.5%and a specificity of 77.9%.Conclusions:The calcification score of coronary artery can influence the CT-FFR value and can predict the occurrence of functional ischemia.The greater the calcification score,the lower the CT-FFR.Whether uric acid has a corrrelation with CT-FFR in CCS patients needs the further study.
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