Objective:To investigate the feasibility of the extracellular volume fraction(ECV)determined using CT to predict the pathologic grade of colon adenocarcinoma.Methods:A total of 380 patients with pathologically proven colon adenocarcinoma were selected.Pre-operative multi-phase dynamic enhanced CT scans were conducted for all patients.The ECVs of colon cancer lesions were calculated using ROI measurements on unenhanced and equilibrium-phase CT images.According to pathological grade,the patients were divided into a high-grade group(100 patients)and a low-grade group(280 patients).The imaging features and clinical data between the two groups were compared.The correlation between ECV and the pathological grade of colon adenocarcinoma was analyzed with binary logistic regression.ROC curve was used to evaluate the diagnostic efficiency.Results:The multi-factor logistic regression analysis showed that ECV was an independent predictor for the pathological grade of colon adenocarcinoma,with OR of 1.380(95%CI 1.289～1.477).The ROC curve demonstrated that ECV had better diagnostic accuracy in predicting the pathologic grade of colon adenocarcinoma,with the AUC of 0.898(95%CI 0.851～0.947),the sensitivity of 90.0%and the specificity of 91.4%.Conclusion:The ECV determined using enhanced CT is helpful for predicting the pathological grade of colon adenocarcinoma and may contribute to personalized treatment.
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