Objective:To evaluate the feasibility and application value of multi-parameter MRI in predicting cervical lymph node metastasis(CLNM)of oral floor cancer.Methods:A total of 53 patients with oral floor cancer were enrolled and divided into the CLNM group(26 cases,13 cases of unilateral metastasis and 13 cases of bilateral metastasis)and the non-CLNM group(27 cases).All patients underwent MRI and DWI.The patient's age,maximum length diameter of tumor,depth of invasion,the vertical distance between the tumor margin and the midline of oral floor,ADCmin,ADCmean and ADCmax were measured and recorded.Independent sample t test and Mann-Whitney U test were used to compare the differences of parameters between the CLNM group and the non-CLNM group and between the unilateral and bilateral metastasis.The indicators with significant statistical significances were evaluated by ROC curve.Results:There were no statistically significant differences in age,the vertical distance,ADCmean or ADCmax between the CLNM group and the non-CLNM group(all P>0.05).There were significant differences in maximum length diameter,depth of invasion and ADCmin(all P<0.01).Compared with the bilateral CLNM,the vertical distance between the tumor margin and the midline of oral floor in the unilateral CLNM was significantly different(P<0.05),but there were no statistically significant differences in age,maximum length diameter,depth of invasion,ADCmin,ADCmean or ADCmax(all P>0.05).The AUCs of invasion depth,maximum length diameter and ADCmin for predicting CLNM were 0.693,0.817,0.878,taking 47.65 mm,40.35 mm and 0.922×10-3 mm2/s as the optimum cutoff values,the sensitivities were 77.3%,81.4%and 89.3%,the specificities were 70.1%,82.2%and 85.2%,respectively.The AUC of the vertical distance between the tumor margin and the midline of oral floor for predicting bilateral CLNM was 0.760,taking-14 mm as the optimum cutoff value,the the sensitivity and specificity were 92.1%and 62.3%,respectively.Conclusions:On the multi-parameter MRI in patients with oral floor cancer,the depth of invasion,the maximum length diameter and ADCmin can be used as important indicators for predicting CLNM,the vertical distance between the tumor margin and the midline of oral floor is helpful in predicting bilateral CLNM.
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