Objective:To investigate the clinical efficiency of ultrasound-guided microwave ablation(MWA)in the treatment of papillary thyroid microcarcinoma(PTMC)and the influencing factors on nodule volume.Methods:63 low-risk PTMC patients with MWA treatment were collected and followed up 1 day,1,3,6,12 months after MWA,and their clinical efficiency and nodule volume were observed.According to the absorption of nodules,they were divided into the absorbed group(19 cases)and the unabsorbed group(43 cases),and the relevant factors affecting the volume of nodules were analyzed.Result:63 patients underwent complete ablation after MWA,and 1 patient underwent surgery due to cervical lymph node metastasis.After MWA,pain occurred in 1 patient,bleeding in 2 patients,and voice change in 1 patient,all of them recuperated after symptomatic treatment.And there were no other adverse reactions or complications.After MWA,the nodule volume increased sharply in a short time,and recovered to the preoperative level in 6 months after ablation,19 cases had complete nodule absorption in 12 months after ablation,among them,4 cases disappeared in 6 months after ablation.There were no significant differences in the microcalcification,distance from the nearest capsule,TI-RADS category,1-day postoperative nodule volume,ablation time,ablation heat or gender between the two groups(all P>0.05).There were significant differences in age,preoperative nodule volume and energy per unit volume between the two groups(all P<0.05).Conclusions:Ultrasound-guided MWA has a good efficiency and high safety in the treatment of low-risk PTMC.Young,small lesion and high energy per unit volume will have good nodule absorption after MWA.