Objective:To explore the diagnostic value and prognostic predictive value of CT score,interleukin-34(IL-34)and soluble interleukin-2 receptor(SIL-2R)in active tuberculosis(ATB).Methods:2 000 ATB patients were selected as ATB group,and 500 patients without ATB during the same period were selected as the non-ATB group.ATB group were treated with anti-tuberculosis therapy for 6 months and followed up for 3 years,538 cases were with poor prognosis and 1 462 cases with good prognosis.The diagnostic and prognostic value of CT score,IL-34,SIL-2R for ATB were analyzed.Results:The CT score,IL-34,and SIL-2R in the ATB group were significantly higher than those in the non-ATB group(all P<0.05).ROC curve showed that the AUCs of CT score,IL-34,SIL-2R and their combination in diagnosing ATB were 0.859,0.820,0.876 and 0.932,respectively.The sensitivity and specificity for the optimal critical value of CT score were 64.2%and 100.0%,those of IL-34 were 61.7%and 100.0%,those of SIL-2R were 72.7%and 90.2%,and those of their combination were 82.9%and 90.6%.The CT score,IL-34,and SIL-2R in ATB patients with poor prognosis were significantly higher than those in ATB patients with good prognosis(all P<0.05).ROC curve showed that the AUCs of CT score,IL-34,SIL-2R and their combination to predict poor prognosis were 0.851,0.838,0.847 and 0.908,respectively.The sensitivity and specificity for the optimal critical value of CT score were 67.8%and 90.1%,those of IL-34 were 54.8%and 100.0%,those of SIL-2R were 65.6%and 88.4%,and those of the combination were 84.8%and 89.7%.Conclusions:The CT score,IL-34 and SIL-2R of ATB patients are highly expressed.The poorer the prognosis,the higher the CT score,IL-34 and SIL-2R.The combination of CT score,IL-34 and SIL-2R has a high diagnostic value and predictive value for ATB.
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