A preliminary study of dual-energy CT in evaluation for hepatic and splenic hemodynamic parameters in cirrhosis with different Child-Pugh classification
Objective:To investigate the changes of hepatic and splenic hemodynamic parameters and their correlation with the Child-Pugh classification using dual-energy CT iodine image.Methods:Arterial and portal venous phase iodine maps of 48 cirrhotic patients(the cirrhotic group)and 23 control individuals(the control group)were retrieved to measure six parameters:iodine concentration in arterial phase(Ia),iodine concentration in portal venous phase(Ip),portal venous iodine concentration(PVIC),arterial iodine fraction(AIF),splenic iodine concentration in arterial phase(SIa)and splenic iodine concentration in portal venous phase(SIp).48 patients were divided into three subgroups,Child-Pugh A subgroup(27 cases),Child-Pugh B subgroup(14 cases),and Child-Pugh C subgroup(7 cases).One-way ANOVA was used for multiple groups comparisons,and Spearman correlation was used for two-variable correlations.Results:There were significant differences in all six parameters among the four groups(all P<0.001),Ia,AIF and SIa in Child-Pugh A,B,C subgroups were higher than those in the control group(all P<0.05)and Ip and PVIC were lower(all P<0.05).Ia,AIF,SIa and SIp in the cirrhosis group were positively correlated with the Child-Pugh classification(all P<0.05),while Ip and PVIC were negatively correlated(both P<0.05).Conclusions:The hepatic and splenic hemodynamic parameters in cirrhosis patients have differences with those in healthy people.The hepatic and splenic hemodynamic parameters in cirrhosis patients are correlated with the Child-Pugh classification.Dual-energy CT can be used to explore the hemodynamic changes in cirrhosis.
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