首页|基于PET/CT不同勾画方法测量非小细胞肺癌原发灶代谢体积的差异性研究

基于PET/CT不同勾画方法测量非小细胞肺癌原发灶代谢体积的差异性研究

Study of different delineating methods based on PET/CT for measurement of metabolic parameters in primary tumor of non-small cell lung cancer

扫码查看
原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
目的:探讨基于PET/CT不同勾画方法对非小细胞肺癌(NSCLC)代谢参数测量的影响及可重复性分析.方法:回顾性分析79例经病理确诊的NSCLC患者资料,测量原发灶最大标准化摄取值(SUVmax),采取自适应迭代算法(AIA)、固定阈值法(以2.5、3、4为阈值)及相对阈值法(以40%、50%为阈值)测量肿瘤代谢体积(MTV)及糖酵解总量(TLG),比较不同勾画方法所获代谢参数的差异,并分析2位医师测量一致性.结果:不同勾画方法所测MTV差异有统计学意义(χ2=14.759,P=0.011),而TLG差异无统计学意义(χ2=3.013,P=0.698).对于固定阈值法和相对阈值法,阈值越高,测得的MTV和TLG越小,其中相对阈值法测得的MTV和TLG较小.不同勾画方法测得的SUVmax、MTV和TLG可重复性均非常高.2位医师测量的SUVmax、MTV及TLG的一致性均极强(均ICC>0.99).不同勾画方法中相对阈值法(以40%为阈值)无需手动调整次数占比最大,为18.32%,其勾画准确率最高,为91.14%,差异有统计学意义(χ2=11.748,P=0.038).结论:不同勾画方法测得的MTV、TLG的重复性非常高,但测得的MTV之间存在差异,其中以40%为阈值的勾画方法无需手动调整的次数最多,勾画准确率为91.14%,建议在临床工作中使用.
Objective:To evaluate the impact and repeatability of different PET/CT-based delineating methods for the measurement of metabolic parameters in primary tumor of non-small cell lung cancer(NSCLC).Methods:The data of 79 NSCLC patients who underwent 18F-FDG PET/CT examination were retrospectively analyzed.Maximum standardized uptake value(SUVmax)was measured.The metabolic tumor volume(MTV)and total lesion glycolysis(TLG)were calculated by three methods,the adaptive interative algorithm(AIA)method,the absolute threshold method(2.5,3,4),and the relative threshold method(40%,50%).The differences of metabolic parameters measured by different delineating methods were compared.The interobserver consistency on metabolic parameters were analyzed.Results:MTV was statistically different of different delineating methods(χ2=14.759,P=0.011),while TLG was not(χ2=3.013,P=0.698).For the absolute threshold method and the relative threshold method,the higher the threshold value,the smaller the values of MTV and TLG,and MTV and TLG measured by the relative threshold method were smaller.The repeatability was high for SUVmax,MTV and TLG using three different methods,and the interobserver consistency was high(all ICC>0.99).The relative threshold method(40%)had the highest percentage of without manual adjustment of 18.32%and the highest accuracy of 91.14%,with a significant difference(χ2=11.748,P=0.038).Conclusions:MTV and TLG have the high repeatability from different delineating methods,while MTV are different.The relative threshold method(40%)has the highest percentage of without manual adjustment and the highest accuracy,and is recommended for clinical use.

Carcinoma,non-small-cell lungPositron emission tomographyTomography,X-ray computedOutlineReproducibilityMetabolic parameters

朱俊辉、李思叶、黄子康、王静、周伟、陈薏帆、朱玉春

展开 >

江苏大学附属昆山医院/江苏省昆山市第一人民医院核医学科,江苏 昆山 215004

南京医科大学姑苏学院,江苏 苏州 215002

江苏大学医学院,江苏 镇江 212013

癌,非小细胞肺 正电子发射断层成像 体层摄影术,X线计算机 勾画 重复性 代谢参数

江苏大学2023年度医教协同创新基金一般项目昆山市第一人民医院2022年度广仁基金科研课题(临床研究专项)重点项目2023年昆山市级科技专项(社会发展)指导性项目

JDYY2023060KRY-YN2022001KSZ2311

2024

10.3969/j.issn.1672-0512.2024.04.004

中国中西医结合影像学杂志
中国中西医结合学会,山东中医药大学附属医院

中国中西医结合影像学杂志

CSTPCD
影响因子：0.857
ISSN：1672-0512
年,卷(期)：2024.22(4)
  • 5