Objective:To analyze the changes of brain functional connectivity before and after glycemic control in patients with type 2 diabetes mellitus(T2DM)based on the resting-state fMRI functional connectivity method.To explore the effect of glycemic control on brain functional connectivity and cognition.Methods:A total of 24 patients with T2DM(the T2DM group)and 20 healthy volunteers(the control group)were collected.All subjects underwent whole brain scan with 3D-T1WI structural image and BOLD functional image,and underwent cognitive assessment testing(MoCA,MMSE).After obtaining resting-state fMRI data,DPABI software was used to select bilateral posterior cingutate as ROIs for functional connection analysis by seed point-based analysis method,and the differential brain regions were obtained by using the software statistical analysis module.The differential brain regions were used as the templates for correlation test,and the functional connectivity values of the differential brain region in T2DM group were extracted for the correlation analysis with clinical indicators and cognitive scores.Results:Compared with the control group,the functional connectivity values in the T2DM group of the posterior cingutate with the region Ⅷ and the region Ⅳ/Ⅴ in the left cerebellar,the left anterior central gyrus,the right posterior central gyrus,the medial and paracingulate gyrus decreased before glycemic control(FDR correction,all P<0.05),and those of the posterior cingutate with the right superior occipital gyrus,the right superior temporal gyrus,the right anterior central gyrus,the left parietal lobe decreased after glycemic control(FDR correction,all P<0.05).Compared with before glycemic control,the functional connectivity value in the T2DM group of the posterior cingutate with the right occipital lobe increased after glycemic control(Permutation test,TFCE correction,P<0.05).Spearman analysis showed HbA1c reduction degree was positively correlated with MOCA score(r=0.409,P=0.048).Conclusions:The glycemic control can improve brain functional connectivity,and the HbA1c reduction degree is positively correlated with MoCA score,suggesting that glycemic control can improve cognitive function in T2DM patients,and the functional connectivity can be used as a means to evaluate brain function impairment in T2DM patients.
Type 2 diabetes mellitusGlyemic controlCognitive impairmentMagnetic resonance imagingResting state functional connectivity
国家科技期刊平台
NSTL
万方数据
