Relationship between quantitative parameters of CT dynamic contrast-enhanced scan and pathological types,long-term prognosis of targeted therapy in non-small cell lung cancer
Objective:To explore the relationship between quantitative parameters of CT dynamic contrast-enhanced scan and pathological types,long-term prognosis of targeted therapy in non-small cell lung cancer(NSCLC).Methods:A retrospective analysis was performed on the clinical data of 116 patients with NSCLC.All patients were treated with epidermal growth factor receptor(EGFR)for targeted therapy.Before and one month after treatment,CT dynamic contrast-enhanced scan was performed to obtain quantitative parameters,such as perfusion value,peak height(PH),time to peak(Tp).According to status of survival,all patients were divided into the death group(30 cases)and the survival group(86 cases).The relationships between perfusion value,PH,Tp and pathological types,long-term prognosis of targeted therapy were analyzed.Results:Before treatment,there were no significant differences in quantitative parameters of CT dynamic contrast-enhanced scan among patients with different pathological types(all P>0.05).After treatment,perfusion value and PH level decreased,while Tp level increased(all P<0.05).After treatment,perfusion value and PH level in the survival group were even lower than those in the death group,while Tp level was even higher than that in the death group(all P<0.05).ROC curve analysis showed that AUC and cut-off value of perfusion value for predicting long-term prognosis of NSCLC patients were 0.822 and 0.19 mL·min-1·mL-1,those of PH were 0.780 and 57.61 HU,and those of Tp were 0.741 and 89.92 s,respectively,and AUC of combined detection was 0.960,which was greater than that of single index(P<0.05).Conclusions:The quantitative parameters of CT dynamic contrast-enhanced scan are not related to pathological types,but are closely related to long-term prognosis of targeted therapy in NSCLC patients.
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