Objective:To compare and analyze the CT features,measurement parameters,CT values and laboratory indexes of hepatocellular carcinoma(HCC)patients with and without liver cirrhosis.Methods:A retrospective collection of CT data and laboratory indexes from 52 pathological confirmed and untreated HCC patients was made.The CT features were analyzed,and the maximum diameter of portal vein,the volume,the maximum cross-sectional area,CT values of the liver and lesions were measured.52 patients were divided into HCC with cirrhosis group(24 cases)and HCC without cirrhosis group(28 case).The statistical analysis was performed by using Chi-squared test,independent sample t test or Mann-Whitney U test appropriately.The correlations among CT features,measurement parameters and laboratory indexes were analyzed by Spearman correlation test.Results:There were no significant differences in age or gender between the two groups(P=0.073,0.463).There were significant differences in levels of cholinesterase,direct bilirubin,indirect bilirubin and AFP between the two groups(all P<0.05).There were no significant differences in CT features of lesions,the volume and the maximum cross-sectional area of the liver and lesions(all P>0.05).There were significant differences in CT value of hepatic parenchyma in portal vein phase,CT value of lesions in plain scan,ascites and/or splenomegaly situation,the maximum diameter of portal vein between the two groups(all P<0.05).The volume of HCC lesions was positively correlated with necrosis,morphology,metastasis,liver volume and some serum enzyme levels,but negatively correlated with lesion CT values in plain scan,portal vein and delayed phases.In addition,liver cirrhosis was positively correlated with ascites and/or splenomegaly situation,the maximum diameter of portal vein,direct and indirect bilirubin levels and AFP levels.Conclusions:There are no significant differences in CT features or measurement parameters between HCC with cirrhosis and HCC without cirrhosis.Ascites and portal hypertension are more common in HCC with cirrhosis.The size of HCC lesion is closely related to laboratory indexes.
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