A preliminary study of diffusion kurtosis imaging(DKI)and quantitative susceptibility mapping(QSM)in evaluating visual pathway microstructure damage in cerebral palsy children with visual impairment
Objective:To investigate the value of diffusion kurtosis imaging(DKI)and quantitative susceptibility mapping(QSM)in evaluating the changes in the microstructure of visual pathway in cerebral palsy children with visual impairment.Methods:30 cerebral palsy children with visual impairment(the observation group)and 30 healthy volunteers(the control group)underwent conventional MRI,DKI and QSM scan.The mean kurtosis(MK),partial fractional anisotropy(FA),mean diffusivity(MD)and magnetic susceptibility of each ROI in the optic nerve,lateral geniculate body,optic radiation and visual cortex were measured and compared between the two groups.Results:There were statistically significant differences in MK values in the optic nerve,lateral geniculate body,optic radiation and visual cortex between the two groups(all P<0.05).There were statistically significant differences in FA and MD values in the optic nerve,lateral geniculate body and optic radiation between the two groups(all P<0.05).And there were statistically significant differences in magnetic susceptibility in the lateral geniculate body,optic radiation between the two groups(all P<0.05).Conclusions:The combination of DKI and QSM can quantitatively evaluate the microstructure changes of visual pathway in cerebral palsy children with visual impairment,which provides an important imaging basis for noninvasive evaluation of visual pathway damage in cerebral palsy children.
Magnetic resonance imagingDiffusion kurtosis imagingQuantitative magnetic susceptibility imagingVisual pathwayCerebral palsy
国家科技期刊平台
NSTL
万方数据
