Objective:To detect the white matter changes in female migraine patients during the interictal period using DTI as well as its relationship and clinical characteristics.Methods:Forty-three female migraine patients(migraine group)and forty-three matched healthy volunteers(control group)were recruited.DTI and clinical data were acquired during the headache attacks.A tract-based spatial statistics(TBSS)method was used to compare white matter differences between the two groups.Furthermore,Pearson correlation analysis was used to analyze the relationship between DTI metrics and clinical indicators.Results:Compared with the control group,the migraine group demonstrated significantly decreased axial diffusivity in the genu,body and splenium of corpus callosum,the bilateral superior corona radiata,the bilateral anterior and posterior limb of the internal capsule,the left superior longitudinal fasciculus and right uncinate fasciculus and the right cingulate gyrus(all P<0.05).There were no differences of two groups in fractional anisotropy,mean diffusivity,or radial diffusivity(all P>0.05).Conclusions:Female migraine patients have pain-related white matters axonal damage,which may help elucidate the central mechanisms of migraine.
万方数据
维普
