Application of quantitative CT technique to investigate the correlation between abdominal fat distribution and hyperuricemia in healthy population in physical examination
Objective:To explore the relationship between abdominal fat distribution and hyperuricemia in healthy population in physical examination by quantitative CT(QCT)technology.Methods:A total of 10,887 healthy person in physical examination were included as study subjects.Visceral fat area(VFA)and subcutaneous fat area(SFA)were divided into 4 groups according to the interquartile interval(from Q1 to Q4).Multivariate logistic regression analysis was used to establish four models to assess the correlation between VFA,SFA and hyperuricemia,according to the fully adjusted model,the analysis was stratified according to gender factors.Results:The overall detection rate of hyperuricemia was 20.2%,the detection rate of male was significantly higher than that of female(P<0.05).In the fully adjusted model,the risk of hyperuricemia in Q2,Q3,Q4 group of VFA was 1.73(1.42～2.10),2.44(1.95～3.04)and 2.99(2.32～3.86)times as compared with Q1 group,respectively,trend test P<0.001.The risk of hyperuricemia in Q2,Q3,Q4 group of SFA was 0.95(0.82～1.11),0.99(0.85～1.16)and 1.17(0.97～1.42)times as compared with Q1 group,respectively,trend test P=0.109.Trend test P values of the risk of hyperuricemia in VFA Q2,Q3,Q4 group were less than 0.05 in both men and women,while trend test P values of the risk of hyperuricemia in VFA Q2,Q3,Q4 group were less than 0.05 in men,but greater than 0.05 in women.Conclusions:In the healthy population in physical examination,the increase of VFA is positively correlated with the risk of hyperuricemia,and VFA can be used as an important monitoring indicator for the prevention and treatment of hyperuricemia,while the association between SFA hyperuricemia is found only in men.
万方数据
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