Objective:To evaluate the difference between computed high b-value DWI(cDWI)and acquired high b-value DWI(aDWI)in image quality and diagnostic accuracy in prostate cancer.Methods:A retrospective analysis of clinical data of 56 patients with abnormal prostate specific antigen(PSA)was conducted.The cDWI images with b value of 1,500 s/mm2 were reconstructed from aDWI images with b value of 0 and 800 s/mm2.The lesion contrast of aDWI800,aDWI1,500 and cDWI1,500 images was measured,and the image quality of three groups was scored in five aspects.Two radiologists retrospectively diagnosed all patients using three protocols,protocol Ⅰ(T2WI+aDWI800+ADC),protocol Ⅱ(T2WI+aDWI1,500+ADC)and protocolⅢ(T2WI+cDWI1,500+ADC).The diagnostic efficiencies were evaluated using ROC curves.Results:Among the images of three groups,the image contrast of cDWI1,500 group was 0.39±0.12,which was significantly higher than that of aDWI800 group(0.18±0.10)and aDWI1,500 group(0.22±0.11)(P<0.01).The subjective quality scores of five aspects in cDWI1,500 group were higher than those in aDWI1,500 group(all P<0.01).ROC curve analysis showed that the AUC of protocol Ⅱ and protocolⅢ was significantly higher than that of protocol Ⅰ,while the difference between protocol Ⅱ and protocol Ⅲ was not statistically significant(P=0.149).Conclusions:High b-value cDWI can significantly improve the contrast and overall image quality of prostate cancer lesions,while maintaining diagnostic efficiency comparable to high b-value aDWI without the increased scanning time.It can serve as a good alternative in the diagnosis of prostate cancer.
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