Objective:To explore the value of ultrasound quantitative assessment of bone age in the diagnosis of central precocious puberty(CPP)in girls.Methods:Fifty-eight girls with precocious puberty were prospectively included,according to GnRH stimulation test,they were divided into a central precocious puberty(CPP)group(36 cases)and a peripheral precocious puberty(PPP)group(22 cases).X-ray bone age and ultrasonic bone age were performed within 1 week for 58 cases.The consistency between X-ray bone age and ultrasound bone age was analyzed,and the ultrasound bone age difference(BAD)and ultrasound bone age index(BAI)were compared between the two groups.ROC curve was used to analyze the sensitivity,specificity and AUC of BAD and BAI in the diagnosis of CPP.Results:The consistency of ultrasound bone age and X-ray bone age in the diagnosis of CPP in girls was high(K=0.771).The Bland-Altman plot showed that 96.6%(56/58)scatter points were evenly distributed within the upper and lower 95%CI reference lines,and the mean difference was-0.18,indicating a strong consistency between the two methods.The ultrasound BAD and BAI of the CPP group were higher than those of the PPP group(t=5.539,4.943,both P<0.001).The AUCs of the BAD and BAI in the CPP group were 0.841 and 0.820,the sensitivities were 88.9%and 72.2%,and the specificities were 68.2%and 77.3%,respectively.Conclusions:Ultrasound bone age is in good agreement with X-ray bone age.Quantitative assessment of bone age by ultrasound has certain value in the diagnosis of CPP in girls.
UltrasonographyBone age indexCentral precocious puberty
万方数据
维普
