The Therapeutic Efficacy of Modified Yanghe Decoction on Knee Osteoarthritis of Cold Dampness Obstruction Type and Its Impact on Inflammatory Factors
Objective:To explore the clinical efficacy of modified Yanghe decoction on the treatment of knee osteoarthritis(KOA)patients with cold dampness obstruction and its impact on inflammatory factors.Methods:90 patients with KOA were selected and randomly divided into an observation group of 45 cases and a control group of 45 cases by using random number table method.The observation group was treated with modified Yanghe decoction combined with celecoxib,while the control group was treated with celecoxib for 4 weeks.The changes in visual analogue scale(VAS)scores,traditional Chinese medicine(TCM)symptom scores,Western Ontario and McMaster Universities(WOMAC)levels,and inflamma-tory factors were observed before and after treatment in both groups of patients.Results:There was no statistically signifi-cant difference(P＞0.05)in VAS scores,TCM syndrome scores,and WOMAC levels between the two groups of patients before treatment.Compared with the control group,the VAS scores,TCM syndrome scores,and WOMAC levels in the observation group decreased significantly after treatment,with a statistically significant difference(P＜0.05).There was no statistically significant difference(P＞0.05)in the levels of inflammatory factors between the two groups of patients before treatment.Compared with the control group,the observation group had IL-1,IL-6,TNF-α levels after treat-ment,MMP-3 and MMP-9 significantly decreased,with sta-tistically significant differences(P＜0.01).Conclusion:Mod-ified Yanghe decoction can effectively alleviate the clinical symptoms of KOA patients with cold dampness obstruction type,improve knee joint function,promote joint function recovery,and treat KOA.Its mechanism may be related to the reduction of inflammatory factors IL-1,IL-6,and TNF-αreducing joint inflammatory response and downregulating the levels of MMP-3 and MMP-9 are related to reducing carti-lage damage.
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