The Correlation between Traditional Chinese Medicine Syndrome Types,Inflammatory Indicators,and High-Frequency Ultrasound Changes in 207 Patients with Knee Osteoarthritis
Objective:To investigate the relationship between different TCM syndrome types and inflammation index and high-frequency ultrasound changes in patients with knee osteoarthritis(KOA).Methods:Retrospective and cross-section investigation was conducted to classify KOA patients into five types according to TCM syndrome differentiation criteria:deficiency of liver and kidney,cold-dampness obstruction,damp-heat obstruction,phlegm-stasis obstruction and Qi-blood weakness.The correlation between different TCM syndrome types and inflammatory indicators erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),hypersensitive C-reactive protein(hs-CRP)and changes under high-frequency ultrasound was analyzed.Results:207 KOA patients were included in the study,including 71 cases of damp-heat obstruc-tion,60 cases of liver and kidney deficiency,31 cases of cold-dampness obstruction,28 cases of phlegm-stasis obstruction,and 17 cases of Qi-blood weakness.The expression levels of ESR and CRP in damp-heat impediment syndrome were high-er than those in other 4 syndrome types(P＜0.05).The expression levels of ESR and hs-CRP in damp-heat impediment syndrome were higher than those in other 4 syndrome types(P＜0.05).The positive rate of synovial blood flow signal was higher in damp-heat Bi syndrome than in liver and kidney deficiency syndrome(P＜0.05).The synovial hyperplasia score of damp-heat obstruction syndrome was higher than that of the other 4 syndrome types(P＜0.05).Conclusion:The main syndromes of patients with KOA are dampness-heat obstruction syndrome,liver and kidney deficiency syndrome,and the level of inflammation indicators and the manifesta-tions of high-frequency ultrasound have a certain relationship with TCM syndromes.Inflammation index combined with high-frequency ultrasound can provide a certain objective basis for TCM syndrome differentiation and classification of KOA.
knee osteoarthritistype of syndromeindicators of inflammationjoint ultrasound
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