首页|加味当归芍药散治疗脾虚湿瘀痹阻型膝骨关节炎的临床疗效观察

加味当归芍药散治疗脾虚湿瘀痹阻型膝骨关节炎的临床疗效观察

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目的:观察加味当归芍药散治疗脾虚湿瘀痹阻型膝骨关节炎的临床疗效。方法:选择符合纳入标准的受试者82例,以随机数字表法将其分为治疗组和对照组,每组41例;治疗组予加味当归芍药散颗粒剂内服治疗,对照组口服塞来昔布胶囊,两组均连续治疗4周,记录两组受试者治疗前后的西安大略和麦克马斯特大学(WOMAC)骨关节炎指数、Lysholm评分、视觉模拟量表(VAS)评分以及疗效指数判断其疗效,记录整个治疗过程中的不良反应以评价其安全性,并在结束治疗6个月后进行随访,记录其复发率。结果:结束治疗后,治疗组VAS评分和WOMAC评分均低于对照组,差异有统计学意义(P<0。05);治疗组Lysholm评分高于对照组,差异有统计学意义(P<0。05)。治疗组的总有效率(92。68%)优于对照组(80。49%),治疗组的复发率(10。50%)低于对照组(30。30%)。治疗期间各组未见明显不良反应。结论:加味当归芍药散在改善脾虚湿瘀痹阻型膝骨关节炎患者疼痛及功能障碍方面的效果更明显,且复发率低,无不良反应及毒副反应,用药安全性高,可广泛应用于临证治疗。
Observation on the Clinical Efficacy of Danggui Shaoyao Powder on the Treatment of Knee Osteoarthritis with Dampness-Stasis Obstruction
Objective:To observe the clinical efficay of Danggui Shaoyao powder on the treatment of knee osteoarthritis with dampness-stasis obstruction.Methods:82 subjects meeting the inclusion criteria in our hospital were selected and divided into treatment group and control group by random number table method,with 41 cases in each group.The treat-ment group was orally treated with Danggui Shaoyao powder supplemented granules,while the control group was orally treated with cecoxib capsule.Both groups were treated for 4 weeks continuously.The efficacy of the two groups was eval-uated by recording the results of Western Ontario and McMaster Universities(WOMAC)osteoarthritis index,Lysholm scores,visual analogue scale(VAS)scores and efficacy index before and after treatment,and the adverse reactions during the whole treatment process were recorded to evaluate its safety.The recurrence rate was recorded at 6 months after the end of treatment.Results:VAS and WOMAC scores in the treatment group were lower than those in the control group af-ter treatment(P<0.05).Lysholm scores in the treatment group were higher than those in the control group(P<0.05).The total effective rate of the treatment group(92.68%)was better than that of the control group(80.49%),the recur-rence rate of the treatment group was 10.50%,lower than 30.30%of the control group,and no obvious adverse reactions were observed in each group during treatment.Conclusion:Danggui Shaoyao powder can improve the pain and dysfunction of patients with damp-stasis arbi knee osteoarthritis more obviously,and the recurrence rate is low,no adverse reactions and side efficacy,high drug safety,and can be widely applied to clinical treatment.

Danggui Shaoyao powderknee osteoarthritiswet stasis arthralgia type

周海东、卢姚宏、王力、胡梁深、周明、龚礼、于江涛、陶志强、范少勇

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江西中医药大学(南昌,330004)

江西中医药大学附属医院

南昌市洪都中医院

加味当归芍药散 膝骨性关节炎 脾虚湿瘀痹阻型

2024

中国中医骨伤科杂志
中华中医药学会,湖北省中医药研究院

中国中医骨伤科杂志

CSTPCD
影响因子:0.732
ISSN:1005-0205
年,卷(期):2024.32(5)
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