Study on the Correlation between Systemic Immune-Inflammation Index and Osteoporosis
Objective:Systemic immune-inflammation index can reflect the inflammatory and immune state of the body.This study aims to explore the correlation between systemic immune-inflammation index(SII)and bone mineral density(BMD),and if this index can be used to diagnose osteoporosis.Methods:272 patients with blood routine examination and BMD measurement from January 2023 to October 2023 were prospectively analyzed.Platelet counts,neutrophil counts,and lymphocyte counts were collected to calculate SII.Bi-nary logistic regression and receiver operating characteristic(ROC)curve analysis was used to analysis the correlation between SII and osteoporosis and the optimal cut-off value.Spearman grade correlation was used to explore the link between BMD and SII.Results:SII is significantly related to the osteoporosis(P＜0.001).The SII of patients with osteoporosis was significantly higher than that of pa-tients without osteoporosis(P＜0.001).SII is significantly related to BMD(L1-L5,r=0.425,P＜0.001;femora neck,r=0.363,P＜0.001).ROC curve showed the diagnostic accuracy(area under curve(AUC)-0.787)and the optimal cut-off value(613.03).Conclusion:SII shows a negative correlation with BMD in people over 50 years old.Patients have a higher risk of osteopo rosis when SII is higher than 613.03.
systemic immune-inflammation indexosteoporosisbone mineral densityinflammationblood routine examination
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