外泌体影响关节软骨再生修复及软骨下骨骨代谢平衡的研究进展
The Mechanism and Application Progress of Exosomes in the Treatment of Osteoarthritis
严铮 1徐妍 2刘应泉 1吴连国3
作者信息
- 1. 浙江中医药大学第二临床医学院(杭州,310053)
- 2. 浙江中医药大学护理学院
- 3. 浙江中医药大学附属第二医院
- 折叠
摘要
外泌体作为一种细胞释放到胞外的小型囊泡,是细胞间通信与物质呈递的天然运输载体,其内含诸多来自分泌细胞的生物活性物质,包括各类核糖核酸、蛋白质、脂质、转录因子以及细胞因子受体等.随着对外泌体及其内含物研究的不断深入,发现外泌体可以通过影响软骨细胞、破骨细胞和成骨细胞的生存和功能,在骨关节炎软骨及软骨下骨的修复与重塑中发挥重要作用,有巨大的治疗潜力.本文主要从外泌体调控软骨细胞的增殖、分化、代谢、程序性细胞死亡,影响软骨下骨成骨细胞和破骨细胞的功能等方面论述其在关节软骨再生修复以及软骨下骨骨代谢平衡中的作用机制.
Abstract
Exosomes as small vesicles released by cells into the extracellular space,are natural transport carriers for inter-cellular communication and material presentation.It contains many biologically active substances from secretory cells,in-cluding various types of ribonucleic acids,proteins,lipids,transcription factors,and cytokine receptors.With the deepening of the research on exosomes and their inclusions,it is found that exosomes can regulate the microenvironment of articular cavity by affecting the survival and function of chondrocytes,osteoclasts and osteoblasts,and play an important role in the repair and remodeling of osteoarthritis cartilage and subchondral bone,showing great therapeutic potential.This article mainly discusses the mechanism of exosomes in the regeneration and repair of articular cartilage and the metabolic balance of subchondral bone from the aspects of regulating the proliferation,differentiation,metabolism,programmed cell death of chondrocytes,affecting the function of osteoblasts and osteoclasts in subchondral bone.
关键词
外泌体/骨关节炎/关节软骨/软骨细胞/软骨下骨Key words
exosome/osteoarthritis/articular cartilage/chondrocyte/subchondral bone引用本文复制引用
基金项目
浙江省中医药现代化专项(2021ZX009)
浙江中医药大学科研项目(2023JKZKTS41)
出版年
2024
国家科技期刊平台
NSTL
万方数据