Objective:To investigate the expression levels and clinical significance of adipocytokine-13(Apelin-13)and fibroblast growth factor 21(FGF21)in the serum of postmenopausal osteoporosis patients.Methods:60 postmenopausal osteoporosis patients from June 2021 to January 2023 were collected as the osteoporosis group,additionally,60 postmeno-pausal patients with reduced bone mineral density(reduced bone mineral density group)and 60 healthy volunteers with normal bone mineral density(normal bone mineral density group)who were treated during the same period and matched with the general information of the osteoporosis group were collected.The levels of serum Apelin-13 and FGF21 in each group were compared;Pearson method was applied to analyze the correlation between serum Apelin-13 and FGF21 levels,bone mineral density,and bone metabolism indicators in postmenopausal osteoporosis patients;Receiver operating charac-teristic(ROC)curve was applied to analyze the predictive value of serum Apelin-13 and FGF21 levels for postmenopausal osteoporosis.Results:The bone mineral density of neck of femur,femoral trochanter,lumbar vertebrae,and the levels of serum Apelin-13 and FGF21 in osteoporosis group were ob-viously lower than those in reduced bone mineral density group and normal bone mineral density group,the bone mineral density of neck of femur,femoral trochanter,lumbar verte-brae and the levels of serum Apelin-13 and FGF21 in the reduced bone mineral density group were obviously lower than those in the normal bone mineral density group(P＜0.05).The serum levels of β isomer of C-terminal telopeptide of typeⅠ collagen(β-CTX)and procollagen type 1 amino-terminal propeptide(P1NP)in the osteoporosis group were obviously higher than those in the reduced bone mineral density group and the normal bone mineral density group(P＜0.05),the serum levels of β-CTX and P1NP in the reduced bone mineral density group were obviously higher than those in the nor-mal bone mineral density group(P＜0.05).Serum Apelin-13 and FGF21 levels in postmenopausal osteoporosis patients were obviously positively correlated with bone mineral density of neck of femur,femoral trochanter and lumbar spine(P＜0.05),and obviously negatively correlated with β-CTX and P1NP(P＜0.05).The combined prediction of Apelin-13 and FGF21 for postmenopausal osteoporosis had an area under the curve(AUC)of 0.903,sensitivity of 83.33％,and specific-ity of 86.67％,which was superior to the individual prediction of Apelin-13 and FGF21(Zcombined detection-Apelin-13=2.945,Zcombined detection-FGF21=2.617,P=0.003,0.009).Conclusion:The serum levels of Apelin-13 and FGF21 in postmenopausal os-teoporosis patients are obviously decreased,and the combination of the two has good predictive value for postmenopausal osteoporosis.
adipocytokine-13fibroblast growth factor 21postmenopausal osteoporosispredictive value
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