Research Progress on the Mechanism of Naringin Mediating Osteoblast to Promote Bone Formation
Osteoporosis(OP)is a systemic metabolic disease caused by an imbalance between bone resorption and bone formation.In recent years,the Bushen,gluten-bone prescription of Fortune's Drynaria Rhizome Decoction has definite clin-ical efficacy against OP.Naringin,its main active ingredient,can effectively regulate the differentiation of osteoblasts and promote bone formation,thus playing an important role in bone reconstruction.The active ingredients and derivatives of traditional Chinese medicine are one of the innovative ways to develop original anti-OP drugs.In this paper,the mechanism of naringin mediating osteoblasts to promote bone formation was discussed and summarized in order to provide theoretical basis for clinical development of anti-OP drugs.This paper summarizes the latest studies and finds that naringin mainly regulates osteoblasts to promote bone formation through MAPK pathway,SDF-l/CXCR4 pathway,PI3K/AKT pathway,Wnt/β-catenin pathway and ER pathway.This paper will focus on the above 5 signaling pathways.
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