Study on the Characteristics of Interleukin-1β Concentration in Synovial Fluid of Patients with Knee Osteoarthritis with Different Syndromes
Objective:To study the characteristics of interleukin-1β(IL-1β)concentration in individuals with two distinct knee osteoarthritis syndromes,and the relationship between the syndrome score and the features of IL-1β concentration.Methods:79 patients in all with knee osteoarthritis were enrolled as the subjects.The patients were divided into two groups:stagnation of phlegm and blood stasis syndrome group and liver and kidney deficiency syndrome group according to the diagnostic criteria of traditional Chinese medicine(TCM)syndromes.The joint fluid samples of the two groups were collected and analyzed to compare the difference of IL-1β concentration in two groups,and the correlation between the concentration characteristics of IL-1β in synovial fluid and the score of TCM syndrome was analyzed.Results:The concen-tration of IL-1β varied significantly between the two groups,in patients with stagnation of phlegm and blood stasis syn-drome,the concentration was higher than that in liver and kidney deficiency syndrome(P＜0.05).The correlation between the IL-1β concentration in stagnation of phlegm and blood stasis syndrome and the syndrome score was positive and statis-tically significant(r=0.389,P＜0.05),and there was no correlation between the syndrome score and the IL-1β concentra-tion in liver and kidney deficiency syndrome(r=0.146,P＞0.05).Conclusion:The concentration features of IL-1β in synovial fluid vary across patients suffering from different syndromes.Patients with blood stasis and stagnation of phlegm syndrome may have varying concentrations of IL-1β,which may indicate a correlation between the severity of the syndrome and the characteristics of the various inflammatory factor concentrations among patients with osteoarthritis of the knee.
knee osteoarthritisstagnation of phlegm and blood stasis syndromeliver and kidney deficiency syndromejoint fluidinterleukin-1β
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