Clinical Efficacy of Shi's Qi-Tao Huayu Decoction on Prevention of Deep Vein Thrombosis after Total Knee Arthroplasty
Objective:To analyze and evaluate the efficacy of Qi-Tao Huayu decoction by Professor Shi Qi on the prevention of deep vein thrombosis(DVT)after total knee arthroplasty(TKA),so as to provide evidence-based basis for the clinical promotion of this prescription.Methods:A total of 110 patients who needed TKA from May 2023 to December 2023 were enrolled in this randomized,controlled,single-blind trial.According to interventions,they are divided into observation group and control group,55 cases in each group.The observation group patients were treated with Qi-Tao Huayu decoc-tion,the control group patients took Livashaban orally.Both groups were followed up 14 d,follow-up content including coagulation function,blood routine,inflammation index,traditional Chinese medicine(TCM)syndrome scores,etc.Results:All 110 patients completed the follow-up,and no case dropped out.After 14 d of treatment,there was no significant difference in coagulation function indexes(D-dimer,fibrino-gen,prothrombin,activated partial thromboplastin time)between the observation group and the control group,but there was significant difference in prothrombin time between the two groups(P＜0.05).After 14 d of treatment,the observation group patients with blood routine indexes(red blood cell count,hemoglobin,platelet count,lymphocyte count)compared with control group,there was no statistically signifi-cant difference,neutrophil count compared with control group,the difference was statistically significant(P＜0.05).After 14 d of treatment,the observation group blood sedimentation,neutrophils and lymphocytes in patients with improved ratio is better than that of control group,the difference was statistically significant(P＜0.05),C-reactive protein compared with control group,there was no statistically significant difference.The overall effective rate of TCM syndrome score in the observation group was higher than that in the control group(P＜0.05).There was no DVT in the two groups,and there was no significant difference in the incidence of adverse events.Conclusion:Shi's Qi-Tao Huayu decoction can effec-tively prevent DVT after TKA,and the incidence of adverse reactions is low,which is worthy of promotion.
total knee arthroplastydeep vein thrombosisQi deficiency and blood stasiscoagulation function
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