Clinical Observation of Platelet-Rich Plasma Combined with Bushen Huoluo Decoction on the Treatment of Knee Osteoarthritis
Objective:To observe the clinical efficacy of platelet-rich plasma combined with traditional Chinese medicine(TCM)Bushen Huoluo decoction on the treatment of knee osteoarthritis.Methods:A total of 120 patients with knee oste-oarthritis diagnosed by Western medicine and liver and kidney deficiency syndrome in TCM were screened and divided into control group and observation group,with 60 cases in each group.The control group was treated with intramuscular bone ultrasound-assisted injection of platelet-rich plasma in the knee joint cavity,and the observation group was treated with in-tramuscular bone ultrasound-assisted injection of platelet-rich plasma in the knee joint cavity at the same time of taking TCM Bushen Huoluo decoction for 5 weeks.The clinical efficacy of the patients was evaluated by TCM syndrome dialecti-cal evaluation,and the scores of VAS,WOMAC and SF-36 before and after treatment were recorded.The levels of IL-1β,IL-6 and TNF-α in synovial fluid were measured,and the therapeutic effect was evaluated.Results:After treatment,the scores of VAS,WOMAC and SF-36 in the two groups were significantly improved,and the scores of the observation group were significantly better than those of the control group.After treatment,the levels of IL-1β,IL-6 and TNF-α in the two groups were significantly decreased,and the levels of inflammatory factors in the observation group were significantly low-er than those in the control group,and the curative effect was better than that in the control group.Conclusion:Platelet-rich plasma injection combined with Bushen Huoluo decoction can reduce the expression of inflammatory factors and im-prove the TCM symptoms,so as to improve the clinical symptoms of knee osteoarthritis,enhance the therapeutic efficacy,and improve the quality of life of patients.
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