痰热清注射液治疗癌性发热有效性及安全性的系统评价
A Systematic Review on the Efficacy and Safety of Tanreqing on FUO in Cancer
汪成琼 1胡小艳 1田应彪 2陈灵 2马虎 3肖政1
作者信息
- 1. 遵义医学院附属医院遵义医学院循证医学中心,循证医学教育部网上合作研究中心遵义医学院分中心,贵州遵义563000
- 2. 遵义医学院附属医院,贵州遵义563003
- 3. 遵义医学院附属医院附属肿瘤医院,贵州遵义563003
- 折叠
摘要
目的 系统分析使用痰热清注射液治疗癌性发热的有效性与安全性,为临床优化治疗方案提供依据.方法 系统检索CBM、CNKI、维普、万方、Pubmed及Embase数据库,采用Cochrane系统评价手册质量评价标准评价纳入研究质量,Meta分析提取数据.结果 1)纳入7个随机对照研究,615例癌性发热患者,纳入研究质量不高;2)与解热镇痛组比较,痰热清注射液组临床治愈率、总体疗效Meta分析合并RR值为1.60(1.33,1.93)、1.33(1.22,1.45);与双黄连比较,临床治愈及总体疗效分别为1.84(1.38,2.44),1.47(1.28,1.69);与消炎痛比较,总体疗效为1.27(1.07,1.51);与新癀片比较,临床治愈及总体疗效分别为2.18(1.09,4.37)、1.26(1.04,1.53),以上差异均有统计学意义.3)与双黄连联合消炎痛比较,临床治愈、临床好转及总体疗效分别为1.21(0.85,1.71)、0.86(0.35,2.10)及1.11(0.92,1.33),差异均无统计学意义.结论 本研究表明痰热清注射液具有较强解热功效,疗效优于双黄连、新癀片及消炎痛,且与消炎痛联合双黄连相当,安全性较好.但纳入研究质量一般,建议临床慎用.
Abstract
Objective: To provide the evidences for the clinical strategies by systematically reviewing all related studies about Tanreqing for fever of unknown origin (FUO) in cancer and analyze its efficacy and safety.Methods: All related studies were retrieved in CBM, CNKI,VIP,Wanfang,Pubmed and Embase;the quality of all included studies was evaluated by Cochrane scale;all data was analyzed by meta-analysis.Results: Seven RCTs involving 615 FUO patients were included,with general methodological quality in most trials.Compared with the Antipyretic analgesic group,the merged RR values of Meta-analysis of clinical cure and overall effect in Tanreqing injection group were as follows: 1.60 (1.33,1.93) and 1.33 (1.22,1.45).Compared with Shuanghuanglian group ,the clinical cure and overall effect were as follows: 1.84 (1.38,2.44) and 1.47 (1.28,1.69).Compared with Indomethacin group,the overall effect was 1.27 (1.07,1.51).Compared with Xinhuang Pian group,the clinical cure and overall effect were as follows: 2.18 (1.09,4.37) and 1.26 (1.04,1.53).All these were statistically significant.Compared with Indomethacin and Shuanghuanglian group, the clinical cure, clinical effectiveness and overall effect were as follows : 1.21 (0.85,1.71), 0.86(0.35,2.10) and 1.11 (0.92,1.33) and these was no statistically significant.Conclusion: The study shows that compared with Indomethacin,Shuanghuanglian and Xinhuang Pian, Tanreqing injection has a strong antipyretic effect which is similar with the Indomethacin and Shuanghuanglian with good security.But the quality of all studies is not high.Therefore,careful application of Tanreqing injection is recommended in clinical therapy.
关键词
痰热清注射液/癌性发热/Meta分析/系统评价Key words
Tanreqing injection/Fever of Unknown Origin (FUO)/Meta analysis/Systematic review引用本文复制引用
基金项目
贵州省哲学社会科学规划基金(14GZYB58)
遵义医学院博士启动基金(F-617)
出版年
2015
国家科技期刊平台
NSTL
维普
万方数据