Effect of Jugou Xiaoyao Powder on Plasma ET-1,CGRP and NPY Levels in Patients with Residual Dizziness Caused by Liver Depression after Manual Reduction of Otolithiasis
Objective:To observe the efficacy of Jugou Xiaoyao Powder in treating residual dizziness(RD)caused by liver depression after manual reduction of otolithiasis,and its influence on plasma levels of endothelin-1(ET-1),calcitonin gene-related peptide(CCRP)and neuropeptide Y(NPY).Methods:A total of 90 patients with liver depression type RD were randomly divided into control group,Chinese medicine group and combined group,with 30 cases in each group.The control group took betahistine mesilate tablet orally,the Chinese medicine group took Jugou Xiaoyao Powder orally,and the combined group took Jugou Xiaoyao Powder and betahistine me-silate tablet orally.After 2 weeks of treatment,the clinical efficacy,DHI score,SAS score and the changes of ET-1,CGRP and NPY in plasma were observed.Results:The total effective rate of the combined group was 93.33％,which was higher than 82.76％of the Chinese medicine group and 66.67％of the control group(P＜0.05).The DHI and SAS scores in the three groups were all lower than those before treatment(P＜0.01),and the scores in the traditional Chinese medicine group and the combined group were lower than those in the control group(all P＜0.01),while there was no significant difference between the traditional Chinese medicine group and the combined group(P＞0.05).The contents of ET-1 and NPY in the three groups were lower than those before treatment(all P＜0.01),and the contents of ET-1 and NPY in the traditional Chinese medicine group and the combined group were lower than those in the control group(all P＜0.01),and there was no significant difference between the tradi-tional Chinese medicine group and the combined group(P＞0.05).After treatment,the CGRP content of the three groups was higher than that before treatment(all P＜0.01),and the CGRP content of the traditional Chinese medi-cine group and the combined group was higher than that of the control group,and the CGRP content of the com-bined group was higher than that of the traditional Chinese medicine group(all P＜0.01).During the treatment,there were 2 cases of constipation in the control group,1 case of gastric discomfort in the traditional Chinese medi-cine group,and 1 case of constipation in the combined group,and no other obvious adverse reactions were ob-served in each group.Conclusion:Jugou Xiaoyao Powder is effective in the treatment of RD,and can relieve anx-iety and improve residual dizziness.Its mechanism may be related to the regulation of plasma ET-1,CGRP and NPY levels.
NETL
NSTL
维普
万方数据
