Mechanism of Fuzheng Jiedu Decoction in the Treatment of Community-acquired Pneumonia Based on Network Pharmacology and Molecular Docking
Objective:To explore the possible mechanism of Fuzheng Jiedu Decoction in treatment of communi-ty-acquired pneumonia(CAP)based on network pharmacology and molecular docking.Methods:The active ingre-dients and corresponding target proteins of Fuzheng Jiedu Decoction were screened by TCMSP and UniPort data-bases;the target genes of CAP were retrieved from Genecards,OMIM and Disgent databases.GO enrichment analy-sis and KEGG enrichment analysis of pathway were performed in Metascape database;finally,the drug components with high network values and core targets were verified by CB-Dock.Results:A total of 215 important active components and 113 core targets for the treatment of community-acquired pneumonia were obtained,the main pathway of CAP was identified,and the active components and the target in molecular docking were identified.Conclusion:Fuzheng Jiedu Decoction has the characteristics of multi-factor cooperative regulation,which pro-vides scientific ideas and basis for further clarifying the mechanism of the treatment of CAP.
万方数据
维普
