Clinical Study of Youhua Yantiao Granules in the Treatment of Septic Shock with the Pattern of Internal Exuberance of Heat-toxin
Objective:To observe the effect of Youhua Yantiao Granules on shock patients with the pattern of in-ternal exuberance of heat-toxin and explore its mechanism.Methods:65 patients were randomly divided into an experimental group and a control group.Among them,33 patients were included in the experimental group,32 pa-tients were included in the control group.The control group received basic western medicine treatment+nasal feeding or oral administration of placebo granules,while the experimental group received basic western medicine treatment+nasal feeding or oral administration of Youhua Yantiao Granules.The treatment courses were all 14 days.The improvement of the 28 day survival rate,APACHE Ⅱ score,SOFA score,blood routine(WBC,N％,CRP),and inflammatory factors(TNF-α,LL-6,IL-8,PCT,lactate,HBP)were analyzed and evaluated.Results:The 28 day survival rate of patients in the experimental group was 78.79％,which was higher than 43.75％in the control group(P＜0.05),and the RR=2.652.There was no significant difference between the two groups in terms of SOFA score and APACHE Ⅱ score,blood routine(WBC,N％,CRP)and biomarkers(TNF-α,IL-6,IL-8,PCT,Lac,HBP)before treatment(all P＞0.05).After 14 days of treatment,the SOFA and APACHE Ⅱ scores in the ex-perimental group decreased compared with those before treatment(all P＜0.05),while the SOFA and APACHE Ⅱscores in the control group were not significantly different before and after treatment(both P＞0.05),and the scores of SOFA and APACHE Ⅱ in the experimental group were lower than those in the control group(all P＜0.05);after the 14th day of treatment,the WBC,N％,CRP,Lac,PCT,TNF-α,IL-6,IL-8 and HBP in the experi-mental group were lower than those before treatment(all P＜0.05),and the levels of each index in the experimen-tal group were lower than those in the control group(all P＜0.05).Conclusion:Youhua Yantiao Granules can im-prove the 28 day survival rate of patients with septic shock,improve inflammation indicators,and have good clini-cal eficacy,which can be further promoted and studied.
Septic shockYouhua Yantiao GranulesPattern of internal exuberance of heat-toxin
万方数据
维普
