A Retrospective Study on the Disease Classification of Sepsis-associated Acute Kidney Injury and the Elements of TCM Syndrome Differentiation
Objective:To investigate the correlation between traditional Chinese medicine(TCM)syndrome dif-ferentiation factors and disease classification in patients with sepsis-associated acute kidney injury(SA-AKI).Methods:A retrospective analysis was conducted on in-patients in the Guangdong Provincial Hospital of Chinese Medicine emergency ward.SA-AKI patients from June 2018 to May 2023 were selected as the research subjects.According to the inclusion and exclusion criteria,160 SA-AKI patients were screened out and divided into tran-sient SA-AKI and persistent SA-AKI.The general conditions,TCM clinical diagnosis information,laboratory indi-cators,Sequential Organ Failure Assessment(SOFA)scores,Acute Physiology and Chronic Health Evaluation Ⅱ(APACHEII)scores,underlying diseases,and infection sites were collected on the day of admission,and 28-day mortality were followed.Results:Compared between transient SA-AKI and persistent SA-AKI,the differences of age[(69.48±15.72)vs.(75.90±12.03),P=0.007],creatinine[137.70 μmol/L(115.50,197.25)vs.156.20 μmol/L(133.00,238.25),P=0.031]were statistically significant.In terms of syndrome differentiation,acute deficiency syndrome accounted for the most critical proportion(50.63％),followed by toxic heat syndrome(18.75％),bowel ex-cess syndrome(16.88％),and blood stasis syndrome(13.75％).No statistical difference existed between the propor-tion of different syndromes in transient and persistent SA-AKI(P＞0.05).Compared with patients with non-acute deficiency syndrome,SOFA score[5.00(3.00,9.00)vs.4.00(3.00,6.00),P=0.044]was higher.Conclusion:Based on the early physicochemical characteristics of SA-AKI,it is not possible to predict a patient's AKI classifi-cation.Acute deficiency syndrome is the most prevalent type of syndrome with worse disease severity and progno-sis.Transient SA-AKI is caused by an excess of pathogens and a deficiency of qi,while persistent SA-AKI is characterized by a deficiency of qi and affected by pathogens.
SepsisSepsis-associated acute kidney injuryAcute deficiency syndromeSyndrome differentiationRetrospective study
万方数据
维普
