摘要
目的 观察息风化痰通络颗粒对急性脑梗死患者脂代谢、血液流变学指标及神经功能的影响.方法 80例急性脑梗死患者按随机数字表法分为观察组与对照组各40例,对照组采用常规治疗,观察组在对照组基础上予息风化痰通络颗粒治疗.记录并对比分析两组间脂代谢指标[总胆固醇(TC)、甘油三酯(TAG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)]、血液流变学指标[全血高切黏度(HSV)、血小板黏附率(PAdR)及红细胞比容(HCT)]、脑血流灌注[大脑中动脉舒张末期血流速度(EDV)、收缩期峰值流速(PSV)及平均血流速度(Vm)]、美国国立卫生研究院卒中量表(NIHSS)评分等.结果 治疗后,两组TC、TAG、HDL-C及LDL-C均较治疗前改善(P＜0.05),且观察组明显优于对照组(P＜0.05);治疗后,两组HSV、PAdR、HCT均较治疗前降低(P＜0.05),且观察组明显低于对照组(P＜0.05);治疗后,两组EDV、PSV及Vm均较治疗前升高(P＜0.05),且观察组明显高于对照组(P＜0.05);治疗后,两组NIHSS评分均较治疗前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 息风化痰通络颗粒可改善急性脑梗死患者脂代谢,改善血液流变学指标,增加脑血流灌注,促进神经功能恢复.
Abstract
Objective:To observe the effects of Xifeng Huatan Tongluo Granules on lipid metabolism,hemorhe-ology,and neurological function in patients with acute cerebral infarction.Methods:A total of 80 patients with acute cerebral infarction were selected and randomly divided into an observation group and a control group,with 40 cases each.The control group received routine treatment,while the observation group received treatment with Xifeng Huatan Tongluo Granules on the basis of the control group.The lipid metabolism indicators[total cholester-ol(TC),triglycerides(TAG),high-density lipoprotein cholesterol(HDLC),and low-density lipoprotein cholesterol(LDLC)],blood rheology[whole blood high shear viscosity(HSV),platelet adhesion rate(PAdR),and hematocrit(HCT)],cerebral blood perfusion[middle cerebral artery end-diastolic blood velocity(EDV),peak systolic flow velocity(PSV),and mean blood flow velocity(Vm)],National Institutes of Health Stroke Scale(NIHSS)scores and other levels of the two groups were recorded and compared.Results:After treatment,the levels of TC,TAG,HDLC,and LDLC in both groups improved compared with before treatment(P＜0.05),and the observation group was significantly better than the control group(P＜0.05);after treatment,the levelsof EDV,PSV and Vm in both group sincreased obvisouly(P＜0.05),and the observation group washigher significantly than the controlgroup(P＜0.05);after treatment,the levels of HSV,PAdR,and HCT in both groups decreased compared with before treatment(P＜0.05),and the observation group was significantly lower than the control group(P＜0.05);after treatment,the NIHSS scores of both groups decreased compared with before treatment(P＜0.05),and the observation group was significantly lower than the control group(P＜0.05).Conclusion:Xifeng Huatan Tongluo Granules can improve lipid metabolism,improve blood rheology,increase cerebral blood flow perfusion,and promote neurological function recovery in patients with acute cerebral infarction.
维普
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