Clinical Observation of Yinxing Yangnao Tablet Combined with Alteplase in the Treatment of Acute Ischemic Stroke
Objective:To observe the clinical efficacy of Yinxing Yangnao Tablet in the treatment of acute isch-emic stroke,and to investigate its mechanism of action.Methods:A total of 80 patients were divided into a study group and a control group using a random number table method,with 40 cases in each group.Both groups re-ceived intravenous thrombolytic therapy with alteplase,while the study group received further treatment with Yinx-ing Yangnao Tablet.The levels of serum malondialdehyde(MD A)and superoxide dismutase(SOD),neurological deficit score(NIHSS)and daily living ability(ADL)between the two groups at admission and 1 and 2 weeks after treatment were compared,and the adverse reactions and clinical efficacy of the two groups were recorded.Re-sults:Compared with the data of the two groups at the time of admission,the serum MDA level decreased,and the SOD level increased(all P＜0.01),and the serum MDA levels in the study group were lower than those in the con-trol group at 1 week and 2 weeks after treatment,while the SOD level was higher than that in the control group(all P＜0.01).The NIHSS score of the two groups showed a downward trend and an upward trend after treatment,and the differences between the two groups were statistically significant(all P＜0.01),and the NIHSS scores of the study group were lower than those of the control group at 1 week and 2 weeks after treatment,and the ADL scores were higher than those of the control group(all P＜0.01).The total effective rate of the study group was 95.00％,which was higher than 80.00％of the control group(P＜0.05).There were 2 cases(5.00％)of intracerebral hemor-rhage after thrombolysis in the control group and 1 case(2.50％)in the study group.There was no significant dif-ference in intracerebral hemorrhage between the two groups(P＞0.05).Conclusion:After intravenous thromboly-sis with alteplase for acute ischemic stroke,the combination with Yinxing Yangnao Tablet is safe and effective,which can further improve defective neurological function and restore daily living ability.Its mechanism may be re-lated to antioxidant stress,anti-inflammatory,and other factors.
Acute ischemic strokeAlteplaseYinxing Yangnao TabletOxidative stressClinical study
万方数据
维普
