Clinical Observation of Bupi Tongluo Decoction in the Treatment of Coronary Microvascular Dysfunction
Objective:To explore the clinical effect of Bupi Tongluo Decoction in the treatment of coronary mi-crovascular dysfunction(CMVD).Methods:A total of 100 patients with CMVD were enrolled and randomly divid-ed into observation group and control group,50 cases in each group.The control group was treated with routine western medicine,while observation group was additionally treated with Bupi Tongluo Decoction.All were continu-ously treated for 4 weeks.The clinical curative effect,scores of TCM syndromes,curative effect of electrocardio-gram,angina symptoms[Seattle angina questionnaire(SAQ)],vascular endothelial function[endothelial cell specif-ic molecule-1(ESM-1),endothelin 1(ET-1),nitric oxide(NO)]and inflammatory indexes[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)]in the two groups were com-pared.Results:The response rate of treatment was higher in observation group(94.00％)than the control group(80.00％)(P＜0.05).After treatment,scores of TCM syndromes(chest tightness,dull heart pain,shortness of breath,fatigue,spontaneous sweating,burnout and laziness to speak)were lower in observation group than the con-trol group(P＜0.05).After treatment,improvement of electrocardiogram was better in the observation group than in the control group,and the response rate of electrocardiogram treatment in the observation group(88.00％)was high-er than that in the control group(72.00％)(P＜0.05).After treatment,the SAQ score was higher in observation group(P＜0.05).After treatment,levels of serum ET-1 and ESM-1 were lower in observation group than the con-trol group,while NO was higher in observation group(P＜0.05).After treatment,levels of serum hs-CRP,IL-6 and TNF-α were lower in observation group than the control group(P＜0.05).Conclusion:Bupi Tongluo Decoc-tion combined with routine treatment can effectively reduce scores of TCM syndromes,relieve angina symp-toms,improve curative effect of electrocardiogram,reduce vascular endothelial injury and inflammatory injury in CMVD patients.
Coronary microvascular dysfunctionBupi Tongluo DecoctionClinical symptomCardiac function
万方数据
维普
