Objective:To observe the influence of Zhishi Dahuang Decoction combined with butyphthalide on neurological function and serum oxidative stress level in patients with acute cerebral infarction(ACI).Methods:A total of 92 ACI patients were randomly divided into an observation group(treated with Zhishi Dahuang Decoc-tion combined with butylphthalide)of 46 cases and a control group(treated with butylphthalide)of 46 cases,with a treatment period of 14 days.The clinical efficacy,traditional Chinese medicine symptom scores,neurological function,serum oxidative stress levels,and adverse reactions after treatment were observed.Results:After 14 days of treatment,the levels of serum malondialdehyde(MDA)and nitric oxide(NO)in the observation group were low-er than those in the control group(P＜0.05),and the levels of superoxide dismutase(SOD)were higher than those in the control group(P＜0.05).After treatment,there were statistically significant differences in neurological func-tion scores between the two groups at different time points and interactions(P＜0.05).The observation group had significantly lower scores than the control group after treatment(P＜0.05).After treatment,the total effective rate in the observation group was 95.65％,which was higher than 78.26％in the control group(P＜0.05).After treat-ment,the observation group had lower scores for symptoms such as hemiplegia,hemianesthesia and dizziness than the control group(P＜0.05).After treatment,the incidence of adverse reactions such as gastrointestinal disorders,limb fatigue,unclear speech,and delayed response in the observation group was no different from that in the con-trol group(P＞0.05).Conclusion:The combination of Zhishi Dahuang Decoction and butylphthalide in the treat-ment of ACI patients can improve serum oxidative stress levels,enhance neurological function,enhance clinical ef-ficacy,improve clinical symptoms,and have no obvious adverse reactions.
关键词
急性脑梗死/枳实大黄汤/中医证候评分/神经功能/血清氧化应激水平
Key words
Acute cerebral infarction/Zhishi Dahuang Decoction/Scoring of Traditional Chinese Medicine Symptoms/Neurological function/Serum oxidative stress levels
维普
万方数据