Study on Traditional Chinese Medicine Syndrome Types and Prognostic Risk Factors of Patients with Severe Pneumonia Complicated with Immune Deficiency
Objective:To explore the distribution of TCM syndromes,clinical features and prognostic risk fac-tors in patients with immune deficiency complicated with severe pneumonia admitted to ICU.Methods:Retrospec-tive analysis was performed to include patients with severe pneumonia who were hospitalized in the ICU of Guang-dong Hospital of Traditional Chinese Medicine from January 2021 to December 2022 and met the criteria of im-mune deficiency.According to the outcome status on the 28th day of inclusion,they were divided into the survival group and death group.The general information,TCM syndrome type,etiology and related auxiliary examination in-dexes of the two groups were compared.The difference between the two groups and the risk factors associated with the 28 day prognosis were analyzed.Results:l)The 28-day mortality rate of 104 patients was 55.8％,and there was no significant difference in the general information between the two groups(P＞0.05).2)The distribution of TCM syndrome types in the 104 patients in order from high to low frequency was 32 cases(30.8％)of phlegm-heat obstructing lung,32 cases(30.8％)of phlegm-turbidity obstructing lung,25 cases(24.0％)of interior invasion of pathogen and vital qi collapse,and 15 cases(14.4％)of invasion of pericardium by heat.There was no statisti-cal significance in the distribution of TCM syndrome types between the two groups(P＞0.05).3)Among the 104 patients,67 cases(64.4％)were infected with bacteria,34 cases(32.7％)were infected with fungi,and 13 cases(12.5％)were infected with viruses.4)The invasive mechanical ventilation rate,APACHE Ⅱ score,SOFA score,Lac,ALT,AST,TBIL,Urea,PT,APTT,DDi and FDP of patients in the death group were higher than those in the survival group,with statistical significance(P＜0.05).5)Multivariate logistic regression analysis showed that AP-AHCE Ⅱ score and APTT had statistical significance for 28 day prognosis.Conclusion:The 28-day mortality rate of patients with immune deficiency complicated with severe pneumonia in ICU was 55.8％.Phlegm-heat ob-structing lung syndrome and phlegm-turbidity obstructing lung syndrome were the most common in TCM syndrome differentiation,and there were a large number of pulmonary pathogens detected.APACHE Ⅱ score and APTT could be used as prognoses for patients.
万方数据
维普
