Application of Shenmai Injection in Chronic Obstructive Pulmonary Disease with Respiratory Failure:a meta-analysis
Objective:To conduct a systematic evaluation and meta-analysis on the efficacy and safety of Shen-mai Injection in treating chronic obstructive pulmonary disease(COPD)and respiratory failure.Methods:Databas-es of China National Knowledge Infrastructure,China Science Periodical Database,Chinese Citation Database,Chi-na Biomedical Literature Database,PubMed,Cochrane Library,Web of Science,and Embase were searched to screen out randomized controlled trials of Shenmai Injection in the treatment of COPD and respiratory failure.Rev-Man5.4 software was used for systematic evaluation and meta-analysis of the included studies,and GRADE system was used to estimate the quality of outcome indicators.Results:16 clinical studies were included in this study,with a total of 1 313 patients,667 in the experimental group and 646 in the control group.Shenmai Injection com-bined with conventional western medicine in the treatment of COPD patients with respiratory failure.In the clini-cal total effective rate[OR=3.10,95％CI(2.05～4.70),P＜0.000 01],arterial partial pressure of oxygen[MD=7.98,95％CI(4.97～11.00),P＜0.000 01],arterial partial pressure of carbon dioxide[MD=-8.31,95％CI(-11.11～-5.51),P＜0.000 01],CRP[SMD=-1.64,95％CI(-2.37～-0.91),P＜0.000 01)],FEV1[MD=0.38,95％CI(0.33～0.42),P＜0.000 01)]of the Shenmai Injection combination group,the differences were statistically significant com-pared with control group(P＜0.01);there was no significant difference in FVC between the two groups.GRADE ev-idence classification indicated that the clinical total effective rate,arterial partial pressure of oxygen,arterial par-tial pressure of carbon dioxide,FVC,FEV1 and CRP had low quality evidence.Conclusion:Conventional western medicine combined with Shenmai Injection the treatment of COPD and respiratory failure can improve the total ef-fective rate of clinical treatment,improve hypoxemia or/and carbon dioxide retention,reduce inflammation,with good safety,which is worthy of promotion and application.
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