Clinical Observation of Modified Sanren Decoction Combined with Iricoxib in the Treatment of Acute Gouty Arthritis
Objective:To explore the clinical efficacy of Modified Sanren Decoction combined with irecoxib in the treatment of acute gouty arthritis with syndrome of heat-dampness blockage and its impact on laboratory indi-cators.Methods:A total of 80 patients were randomly divided into a control group and an observation group,with 40 cases each.The control group was treated with iricoxib tablets on the basis of routine treatment,while the obser-vation group was treated with Modified Sanren Decoction on the basis of the control group.All were continuously treated for 7 days.The main symptoms and signs of two groups before and after treatment,dampness and heat con-stitution score,laboratory indicators(UA,ESR,CRP),and serum inflammation indicators TNF-α,IL-6,IL-1β changes were observed;the clinical efficacy and improvement of heat-dampness constitution between the two groups after treatment were compared,and the safety of the two groups treatments was evaluated.Results:After treatment,the scores of acute joint redness and swelling,joint tenderness,joint pain,and joint mobility disorders in both groups were all decreased(P＜0.05),and the scores of the above symptoms and signs in the observation group were lower than those in the control group(P＜0.05);the scores of heavy body drowsiness,bitter and dry mouth,irritated and lax,sticky or dry stools,short and red urine in both groups were all decreased(P＜0.05),and the observation group was lower than the control group(P＜0.05).The levels of UA,ESR,CRP,TNF-α,IL-6,IL-1β in both groups were all decreased(P＜0.05),and the observation group was lower than the control group(P＜0.05).The total effective rate of 92.50％in the observation group was significantly higher than 75.00％in the control group(P＜0.05);the total effective rate of improving heat-dampness constitution in the observation group was 90.00％,which was significantly higher than 72.50％in the control group(P＜0.05).There were no significant adverse reactions related to medication during the treatment period in both groups.Conclusion:The treatment of acute gouty arthritis with Modified Sanren Decoction combined with iricoxib has a significant therapeutic effect on dampness heat blockage syndrome.It can effectively alleviate clinical symptoms,improve dampness heat constitu-tion,regulate physical and chemical examination index levels,and has minimal toxic and side effects.It can pro-vide a new approach for the treatment of acute gouty arthritis with traditional Chinese and western medicine.
Acute gouty arthritisSyndrome of heat-dampness blockageModified Sanren DecoctionHeat-dampness constitutionPhysical and chemical inspection indicatorsInflammatory indicators
万方数据
维普
