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葛根芩连汤加味治疗急性肠炎的临床观察

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目的 探究葛根芩连汤加味治疗急性肠炎的效果.方法 纳入急性肠炎患者共80例,按照随机数字表法分为对照组与观察组各40例.对照组接受奥美拉唑等常规西医治疗,观察组在此基础上加用葛根芩连汤治疗.观察两组疗效,并比较治疗前后中医证候积分、炎症指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)]、白蛋白、前白蛋白及免疫指标[免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)].结果 观察组临床总有效率为95.00%,比对照组的80.00%高(P<0.05).两组治疗后胃脘疼痛、身热不扬、大便稀溏、恶心呕吐评分比治疗前低,且观察组比对照组低(P<0.05);TNF-α、IL-6、hs-CRP及PCT比治疗前低,且观察组比对照组低(P<0.05);白蛋白、前白蛋白、IgG、IgA及IgM比治疗前高,且观察组比对照组高(P<0.05).结论 中西医结合治疗急性肠炎疗效确切,可明显抑制患者炎症反应,改善其血清白蛋白、前白蛋白水平.
Clinical Observation of Gegen Qinlian Decoction in Treating Acute Enteritis
Objective:To explore the effects of Gegen Qinlian Decoction on acute enteritis.Methods:A total of 80 patients with acute enteritis were included,and were divided into the control group and observation group ac-cording to random number table method,with 40 cases in each group.The control group received conventional western medicine treatment such as omeprazole,while the observation group received Gegen Qinlian Decoction on this basis.The curative effect of the two groups were observed,and the TCM syndrome scores,inflammation[tu-mor necrosis factor-α(TNF-α),interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT)]indexes,albumin,prealbumin and immunity[immunoglobulin G(IgG),immunoglobulin A(IgA),immuno-globulin M(IgM)were compared and evaluated in the two groups before and after treatment.Results:The effica-cy of the observation group was 95.00%,which was higher than 80.00%of the control group(P<0.05).After treat-ment,the scores of stomachache,body heat,loose stools,nausea and vomiting in the two groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05).The levels of TNF-α,IL-6,hs-CRP,and PCT in the two group were lower than those before treatment,and the observation group was lower than the control group(P<0.05).After treatment,the albumin and prealbumin in the two groups were higher than those before treatment,and the observation group was higher than the control group(P<0.05).After treat-ment,the levels of IgG,IgA,and IgM in the two groups were higher than those before treatment,and the observa-tion group was higher than the control group(P<0.05).Conclusion:The combination of Chinese and western medicine in the treatment of acute enteritis is effective,which can significantly inhibit the inflammatory response of patients,improve the level of serum albumin and prealbumin.

Acute enteritisGegen Qinlian DecoctionOmeprazoleProcalcitoninAlbumin

李建升、于边芳、焦凤丽

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山东中医药大学附属医院,山东济南 250014

山东中医药大学第二附属医院,山东济南 250000

急性肠炎 葛根芩连汤 奥美拉唑 降钙素原 白蛋白

山东省自然科学基金联合基金山东省中医药科技发展计划

ZR2022LSW0212019-0187

2024

中国中医急症
中华中医药学会

中国中医急症

CSTPCD
影响因子:1.144
ISSN:1004-745X
年,卷(期):2024.33(3)
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