Effect of Qingchang Decoction Combined with Mesalazine for Active Ulcerative Colitis with Syndrome of Dampness and Heat in the Large Intestine
Objective:To observe the efficacy of Qingchang Decoction combined with mesalazine for active ul-cerative colitis(UC)with syndrome of dampness and heat in the large intestine.Methods:88 cases of confirmed UC with syndrome of dampness and heat in the large intestine were divided into two groups according to random number table method(n=44 cases in each group).The two groups were treated by routine measures referring to the consensus of diagnosis and treatment;the control group was given with mesalazine sustained-release granules,and the observation group was treated with Qingchang Decoction on the basis of control group.The two groups were observed for 2 weeks.The therapeutic effect,Sutherland disease activity index(DAI)score,abdominal pain,and quality of life improvement were compared between the two groups.Results:After treatment,the total effec-tive rate of observation group(95.45％)was significantly increased compared with control group(75.00％)(P＜0.05).After treatment,DAI score of the two groups was significantly decreased,and the decrease of the observa-tion group was more evident than that of the control group at the same point(P＜0.05).After treatment,the visual analogue scale(VAS)score of the two groups was significantly decreased,and the decrease was more obvious in the observation group(P＜0.05).After treatment,the inflammatory bowel disease questionnaire(IBDQ)scores of the two groups were significantly decreased,and the decrease was more significant in the observation group(P＜0.05).Conclusion:Qingchang Decoction combined with mesalazine for active UC with syndrome of dampness and heat in the large intestine has an evident efficacy,is beneficial to the control of disease,relieve pain,and im-prove the quality of life of patients.
Ulcerative colitisQingchang DecoctionQuality of lifeSyndrome of dampness and heat in the large intestineMesalazine
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维普
