清金化痰汤联合西医常规治疗对慢性阻塞性肺疾病急性加重期患者临床疗效的Meta分析
Clinical Efficacy of Qingjin Huatan Decoction Combined with Conventional Western Medicine in Patients with AECOPD:a Meta-analysis
邢帅 1张盼盼 2邵旭鹏 1迟培枫 1张铎 3范开亮1
作者信息
- 1. 山东中医药大学附属医院,山东济南 250014
- 2. 山东省济南市章丘区中医医院,山东济南 250200
- 3. 山东中医药大学,山东济南 250355
- 折叠
摘要
目的 通过Meta分析的方法了解慢性阻塞性肺疾病急性加重期(AECOPD)患者应用清金化痰汤联合西医常规治疗对其临床疗效的影响.方法 通过检索中国知网(CNKI)、中文科技期刊数据库(VIP)、中国生物医学文献数据库(CBM)、万方数据库(WanFang)、PubMed、The Cochrane Library等数据库中关于清金化痰汤联合西医常规治疗对AECOPD患者临床疗效的随机对照研究,检索时间限定为建库以来至2023年8月31日.使用Review Manger5.3软件对所提取的数据进行Meta分析.结果 共纳入25篇文献,纳入总数为2 061例,其中观察组1 037例,对照组1 024例.观察组的临床疗效[MD=1.2,95％CI(1.15,1.25),P＜0.000 01]、PO2[MD=4.43,95％CI(3.52,5.35),P＜0.01]、FEV1[MD=0.27,95％CI(0.17,0.37),P＜0.01]、FEV1/FVC％[MD=4.4,95％CI(3.46,5.34),P＜0.01]高于对照组,具有统计学差异;观察组的中医证候积分[MD=-3.2,95％CI(-4.06,-2.34),P＜0.01]、PCO2[MD=-5.93,95％CI(-7.11,-4.76),P＜0.01]、WBC[MD=-0.7,95％CI(-1.05,-0.36),P＜0.01]低于对照组,具有统计学差异.观察组CRP[MD=-2.11,95％CI(-4.57,0.36),P＜0.09]相比于对照组虽有所降低,但差异无统计学意义.结论 清金化痰汤联合西医常规治疗能更好地改善AECOPD患者的症状、肺功能及炎症指标.
Abstract
Objective:To investigate the effect of Qingjin Huatan Decoction combined with conventional west-ern medicine on the clinical efficacy of acute exacerbations of chronic obstructive pulmonary disease(AECOPD)patients by meta-analysis.Methods:Databases of CNKI,VIP,CBM,Wanfang,PubMed and The Cochrane Library were searched from inception to August 31,2023 for randomized controlled studies on the clinical efficacy of Qin-gjin Huatan Decoction combined with conventional western medicine in patients with AECOPD.Meta analysis of the extracted data was performed using Review Manger 5.3 software.Results:A total of 2 061 cases were includ-ed in 25 literatures,including 1 037 cases in the observation group and 1024 cases in the control group.Clinical efficacy of the observation group[MD=1.2,95％CI(1.15,1.25),P＜0.000 01],PO2[MD=4.43,95％CI(3.52,5.35),P＜0.01],FEV1[MD=0.27,95％CI(0.17,0.37),P＜0.01],FEV1/FVC％[MD=4.4,95％CI(3.46,5.34),P＜0.01]were higher than those in the control group,with statistical difference.The TCM syndrome scores of the ob-servation group[MD=-3.2,95％CI(-4.06,-2.34),P＜0.01],PCO2[MD=-5.93,95％CI(-7.11,-4.76),P＜0.01],WBC[MD=-0.7,95％CI(-1.05,-0.36),P＜0.01]were lower than the control group,with statistical difference.CRP in the observation group[MD=-2.11,95％CI(-4.57,0.36),P＜0.09]was lower than that in the control group,but there was no statistical difference.Conclusion:Qingjin Huatan Decoction combined with conventional western medicine can better improve the symptoms,pulmonary function and inflammatory indicators of patients with AECOPD.
关键词
慢性阻塞性肺疾病急性加重期/清金化痰汤/Meta分析/随机对照试验Key words
AECOPD/Qingjin Huatan Decoction/Meta-analysis/Randomized controlled trials引用本文复制引用
基金项目
国家自然科学基金面上项目(82074227)
山东省医药卫生科技发展计划(202117010252)
出版年
2024
NETL
NSTL
万方数据