中药灌肠对急性期溃疡性结肠炎的临床疗效及肠道黏膜修复作用的Meta分析
Clinical Efficacy of Enema with Traditional Chinese Medicine on Acute Ulcerative Colitis and Its Repair Effect on Intestinal Mucosa:a Meta-analysis
徐艺苑 1张聪伟 2刘金响 3史英 3马小兵3
作者信息
- 1. 陕西中医药大学,陕西咸阳 712046
- 2. 陕西中医药大学附属医院,陕西咸阳 712000
- 3. 陕西中医药大学第二附属医院,陕西咸阳 712000
- 折叠
摘要
目的 评价中药灌肠治疗急性期或活动期溃疡性结肠炎(UC)的有效性及对黏膜修复作用的疗效.方法 检索中英文数据库,包括中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、中文科技期刊数据库(VIP)、万方数据库、临床试验注册登记库、PubMed、Embase等,时间为建库至2023年10月,筛选随机对照试验(RCTs),采用RevMan5.3软件对纳入的研究进行Meta分析.结果 共纳入17篇RCTs,Meta分析结果示:总有效率[RR=1.22,95％CI=(1.15,1.28),P＜0.01];腹泻积分[SMD=-1.38,95％CI=(-2.00,-0.77),P＜0.01];脓血便积分[SMD=-1.09,95％CI=(-1.64,-0.53),P＜0.01];Baron 评分[SMD=-1.38,95％CI=(-2.05,-0.70),P＜0.01];黏膜组织评分[SMD=-2.00,95％CI=(-3.35,-0.66),P＜0.01];白细胞介素-6(IL-6)水平[SMD=-3.11,95％CI=(-5.71,-0.50),P=0.02];白细胞介素-10(IL-10)水平[SMD=1.65,95％CI=(1.35,1.95),P＜0.01];肿瘤坏死因子-α(TNF-α)水平[SMD=-1.93,95％CI=(-2.48,-1.39),P＜0.01].结论 中医药灌肠辅助治疗急性期或活动期UC有助于提高治疗效果,缓解腹泻及脓血便的临床症状,促进肠道黏膜修复,抑制炎性因子的释放.
Abstract
Objective:To evaluate the efficacy of Chinese medicine enema in the treatment of acute or active ulcer-ative colitis(UC)and its effect on inflammatory factors.Methods:The Chinese and English databases,including China National Knowledge Infrastructure(CNKI),China Biology Medicine disc(CBM),VIP database,Wanfang Data-base,ClinicalTrials,PubMed,Embase,etc.were searched from inception to September 2023 for randomized con-trolled trials(RCTs),and meta-analysis of the included studies was performed using RevMan5.3 software.Results:A total of 17 RCTs were included,and the results of meta-analysis showed that total effective rate[RR=1.22,95％CI(1.15,1.28),P＜0.01];diarrhea score[SMD=-1.38,95％CI(-2.00,-0.77),P＜0.01];bloody purulent stool score[SMD=-1.09,95％CI(-1.64,-0.53),P＜0.01];Baron score[SMD=-1.38,95％CI(-2.05,-0.70),P＜0.01];muco-sal tissue score[SMD=-2.00,95％CI(-3.35,-0.66),P＜0.01];IL-6 level[SMD=-3.11,95％CI(-5.71,-0.50),P=0.02];IL-10 level[SMD=1.65,95％CI(1.35,1.95),P＜0.01];TNF-α level[SMD=-1.93,95％CI(-2.48,-1.39),P＜0.01].Conclusion:TCM enema-assisted treatment in acute or active stage of UC can improve the therapeutic ef-fect,relieve the clinical symptoms of diarrhea and bloody purulent stool,promote the repair of intestinal mucosa,in-hibit the release of inflammatory factors.
关键词
溃疡性结肠炎/中医药/灌肠/炎性因子/临床症状Meta分析Key words
Ulcerative colitis/Traditional Chinese medicine/Enema/Inflammatory factors/Clinical symptoms/Meta引用本文复制引用
基金项目
国家自然科学基金青年基金(81803951)
陕西省科技厅项目(2022JM-506)
陕西省科技厅项目(2024JC-YBQN-0963)
陕西中医药大学校级项目(2021GP44)
陕西中医药大学第二附属医院科学研究计划(2021YB04)
出版年
2024
NETL
NSTL
万方数据