Clinical Efficacy of Enema with Traditional Chinese Medicine on Acute Ulcerative Colitis and Its Repair Effect on Intestinal Mucosa:a Meta-analysis
Objective:To evaluate the efficacy of Chinese medicine enema in the treatment of acute or active ulcer-ative colitis(UC)and its effect on inflammatory factors.Methods:The Chinese and English databases,including China National Knowledge Infrastructure(CNKI),China Biology Medicine disc(CBM),VIP database,Wanfang Data-base,ClinicalTrials,PubMed,Embase,etc.were searched from inception to September 2023 for randomized con-trolled trials(RCTs),and meta-analysis of the included studies was performed using RevMan5.3 software.Results:A total of 17 RCTs were included,and the results of meta-analysis showed that total effective rate[RR=1.22,95％CI(1.15,1.28),P＜0.01];diarrhea score[SMD=-1.38,95％CI(-2.00,-0.77),P＜0.01];bloody purulent stool score[SMD=-1.09,95％CI(-1.64,-0.53),P＜0.01];Baron score[SMD=-1.38,95％CI(-2.05,-0.70),P＜0.01];muco-sal tissue score[SMD=-2.00,95％CI(-3.35,-0.66),P＜0.01];IL-6 level[SMD=-3.11,95％CI(-5.71,-0.50),P=0.02];IL-10 level[SMD=1.65,95％CI(1.35,1.95),P＜0.01];TNF-α level[SMD=-1.93,95％CI(-2.48,-1.39),P＜0.01].Conclusion:TCM enema-assisted treatment in acute or active stage of UC can improve the therapeutic ef-fect,relieve the clinical symptoms of diarrhea and bloody purulent stool,promote the repair of intestinal mucosa,in-hibit the release of inflammatory factors.
Ulcerative colitisTraditional Chinese medicineEnemaInflammatory factorsClinical symptomsMeta
NETL
NSTL
万方数据
