Effects of Tongnao Yiqi Decoction on Cerebral Blood Perfusion,Nerve Function and Inflammation in Patients with Acute Posterior Circulation Cerebral Infarction
Objective:To observe the effects of Tongnao Yiqi Decoction on cerebral blood perfusion,nerve func-tion and inflammation in patients with acute posterior circulation cerebral infarction.Methods:A total of 80 pa-tients with acute posterior cerebral infarction admitted were selected as the study subjects,and were divided into two groups by completely random method.The control group was given basic symptomatic treatment such as antico-agulation,lipid regulation and nutritional nerve,and the observation group was given Tongnao Yiqi Decoction in ad-dition to basic symptomatic treatment.The differences of cerebral blood perfusion,nerve and inflammation-related factors before and after treatment were detected,and the differences of TCM symptom score,National Institutes of Health Stroke Scale(NIHSS)score and Barthel(BI)score before and after treatment were evaluated.Results:The difference of cerebral blood perfusion was compared,and no difference was found before treatment(P＞0.05).Com-pared between before and after treatment,the mean blood flow,systolic maximum blood flow velocity(Vmax)and diastolic minimum blood flow velocity(Vmin)of the two groups were increased,and the resistance index(RI)was decreased,with significant differences(P＜0.05).After treatment,the average blood flow,Vmax and Vmin were higher and RI was lower in the observation group(P＜0.05).There was no difference in neurological and inflammatory fac-tors before treatment(P＞0.05).Compared between before and after treatment,neurotrophic factor(NTF)was in-creased,while S-100β protein,matrix metalloproteinase-9(MMP-9),neutrophil to lymphocyte ratio(NLR),inter-leukin-6(IL-6),CXC chemokine ligand 16(CXCL16)and neuron-specific enolase(NSE)were decreased in both groups with significant differences(P＜0.05).After treatment,NTF was higher and S-100β protein,MMP-9,NLR,NSE,IL-6 and CXCL16 were lower in the observation group(P＜0.05).The difference of TCM symptom score,NI-HSS score and BI score was compared,and no difference was found before treatment(P＞0.05).Before and after treatment,the TCM symptom score and NIHSS score decreased,BI score increased between the two groups(P＜0.05).The differences after treatment were compared again,and it was found that the TCM symptom score and NI-HSS score were lower and BI score was higher in the observation group(P＜0.05).There was no severe adverse ef-fects in two groups.Conclusion:Tongnao Yiqi Decoction can regulate the expression of nerve and inflammation-related factors,improve cerebral blood perfusion,and promote the recovery of nerve function in the treatment of acute posterior cerebral infarction.
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