Systematic Review and Meta-analysis of Clinical Efficacy and Safety of Traditional Chinese Medicine Oral Formula Combined with Renal Replacement Therapy in the Treatment of Sepsis Introduced Acute Kidney Injury
Objective:To conduct meta-analysis of evaluation of the clinical efficacy and safety of Traditional Chinese Medicine(TCM)oral formula combined with renal replacement therapy(RRT)in the treatment of sepsis introduced acute kidney injury.Methods:From the database's inception to June 17th,2023,the literature in the CNKI,Wanfang database,Chinese Sci-tech Journal Database,Chinese Biomedical Literature Database,Web of Sci-ence,PubMed,Embase,and Cochrane Library was searched for RCT of TCM oral formulas combined with RRT for the treatment of patients with septic acute kidney injury.The Cochrane risk bias assessment method was used to assess the quality of the literature.For data analysis,RevMan 5.4.1 software was employed.Results:A total of 681 patients with septic acute kidney injury were included in 9 RCTs.Compared with RRT alone,TCM oral formu-la combined with RRT could clear TNF-α[MD=-29.48,95％CI(-44.81,-14.15),P=0.000 2],IL-6 level[MD=-28.83,95％CI(-38.84,-18.82),P＜0.000 1],Scr level[MD=-21.86,95％CI(-44.10,0.38),P=0.05],NGAL lev-el[MD=-12.25,95％CI(-16.90,-7.60),P＜0.000 1],Cys C level[MD=-0.45,95％CI(-0.49,-0.42),P＜0.000 1],APACHE Ⅱ score[MD=-3.20,95％CI(-3.89,-2.50),P＜0.000 1],SOFA score[MD=-1.78,95％CI(-2.19,-1.37),P＜0.000 1],the mortality rate[RR=0.42,95％CI(0.26,0.68),P=0.000 4]were all lower.Only one literature re-ported adverse reactions,and no literature reported safety indicators.Conclusion:TCM oral formula combined with RRT can alleviate the inflammatory reaction of patients with septic acute kidney injury,protect the renal func-tion of patients,and reduce the mortality of patients,but the above conclusion still needs to be further verified by a multi center,large sample RCT study.
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