Effect of Traditional Chinese Medicine Enema on Intestinal Mucosal Protection and Inflammatory Factor Levels in Active Ulcerative Colitis:A Meta-analysis
Objective:To systematically evaluate the effects of traditional Chinese medicine(TCM)enema on in-testinal mucosal protection and inflammatory factors in active ulcerative colitis(UC).Methods:Randomized con-trolled trials(RCTS)on the treatment of active UC were searched by China National Knowledge Infrastructure(CNKI),Wanfang,VIP and PubMed.The literatures eligible for inclusion were screened out,data extraction and quality evaluation were carried out,and statistical analysis was carried out using RevMan 5.4 software.Results:A total of 22 literatures with a total of 2 087 patients were included.The results of meta-analysis showed that the Baron endoscopy score,Mayo disease activity index score and mucosal Geboes index score of patients in the TCM enema group were significantly lower than those in the control group(P＜0.05);levels of TNF-α,hs-CRP,IL-1β,IL-4,IL-6,IL-8 were significantly lower than those in control group(P＜0.05);levels of TGF-β1,IL-10 and the clinical effective rate were significantly higher than those in control group(P＜0.05).Conclusion:TCM enema in the treatment of UC can improve the total clinical effective rate,activate the expression levels of IL-10 and TGF-β1,silence pro-inflammatory factors such as TNF-α,hs-CRP,IL-1β,IL-4,IL-6 and IL-8,reduce inflammatory in-filtration,and repair the damaged intestinal mucosa.
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