Effect of Yinhuang Buccal Tablets on Inflammatory Factors Expression in Mice with H1N1 Influenza
Objective:To evaluate the efficacy of Yinhuang Buccal Tablet on mice with H1N1 influenza and to explore its effect on inflammatory factors in H1N1 influenza mice.Methods:H1N1 mouse model was established by nasal drip of influenza virus H1N1CA07.The control group and the observation group were given oseltamivir and Yinhuang Buccal Tablet solution respectively by gavage for 7 days.The changes of inflammatory factors includ-ing IFN-γ,IL-12p70,IL-17A,IP-10,M1P-1β and ENA-78 in serum of mice were detected by high throughput liquid phase protein chip.Results:The diseased lung index of Yinhuang Buccal Tablet group was significantly lower than that of model group.The IL-12p70,ENA-78 and IL-17A water in model group were significantly lower(P＜0.01),and the IP-10 was significantly higher(P＜0.01).IFN-y and MIP-1β levels in the Yinhuang Buccal Tablet group were significantly lower than those of oseltamivir group(P＜0.05).Conclusion:Yinhuang Buccal Tablet could significantly reduce lung injury in H1N1 mice and the levels of IFN-y and MIP-1β.It might reduce the Th1 immune response of influenza mice by reducing the chemotaxis of T cells,thus achieving lung protection.
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