Efficacy and Safety Observation on Modified Xuanbai Chengqi Decoction in the Treatment of Ventilator-associated Pneumonia with Severe Trauma
Objective:To investigate the efficacy and safety of Modified Xuanbai Chengqi Decoction in treating ventilator-associated pneumonia(VAP)patients with severe trauma(syndrome of phlegm-heat obstructing lung).Methods:This study employed a prospective,randomized controlled trial design.60 patients were randomly as-signed to either a treatment group or a control group,each consisting of 30 patients.The control group received ba-sic western medicine treatment,while the treatment group was combined with Modified Xuanbai Chengqi Decoction on the basis of the control group for a 7-day intervention period.Procalcitonin(PCT),C-reactive protein(CRP),white blood cell count(WBC),clinical pulmonary infection score(CPIS),airway resistance(Raw),static compli-ance(Cst),oxygenation index(PaO2/Fi02),duration of mechanical ventilation,intra-abdominal pressure(IAP),inci-dence of high gastric residual volume(GRV),incidence of feeding intolerance(FI),and time to reach enteral nutri-tion goals were observed.The overall clinical efficacy and safety indicators were evaluated in both groups.Re-sults:Compared with the control group,the treatment group showed significantly lower CPIS scores(P＜0.01),higher PaO2/FiO2(P＜0.01),and significantly decreased Raw(P＜0.01)after treatment.The treatment group also exhibited a notably shorter duration of mechanical ventilation(P＜0.01).Compared with the control group,the treatment group had more significant reductions in IAP(P＜0.01),shorter time to reach enteral nutrition goals(P＜0.05),and lower incidences of high GRV(P＜0.05)and FI(P＜0.05).The total effective rate for the treatment group was 90.00％,which was higher than 80.00％in the control group(P＜0.05).Conclusion:Modified Xuanbai Chengqi Decoction demonstrated superior clinical efficacy in assisting the treatment of severe trauma complicated by VAP compared with western medicine alone,and it showed good safety.
Ventilator-associated pneumoniaModified Xuanbai Chengqi DecoctionIntegrated traditional Chi-nese and western medicineSevere trauma
NETL
NSTL
万方数据
