Effect of Shenfu Injection on Inflammatory Index,Cardiac Function and Clinical Efficacy in Patients with Acute Heart Failure
Objective:To observe the efficacy of Shenfu Injection in patients with acute heart failure(syndrome of yang deficiency of heart and kidney)and to explore its mechanism of action.Methods:A total of 89 patients were randomly divided into the observation group(45 cases)and the control group(44 cases)according to random number table method,and both groups were treated with conventional western medicine;the observation group was added with Shenfu Injection on the basis of the control group.Serum inflammatory indexes,hemodynamic indexes,cardiac function and clinical efficacy were compared between the two groups.Results:There was no significant difference in the levels of IL-6,hs-CRP,LVEF,BNP,CK-MB,cTnT and the levels of hemodynamic indexes CO,MAP and PAP between the two groups before treatment(all P＞0.05).On the 5th and 10th days after treatment,the levels of IL-6,hs-CRP,LVEF,BNP,CK-MB,and cTnT and the levels of hemodynamic indexes CO,MAP and PAP in the two groups were improved compared with those before treatment(all P＜0.05),and the improvement of all indicators in the observation group was better than that in the control group in the same period(all P＜0.05).The total effective rate of treatment in the observation group was 86.67％,which was higher than 72.73％in the control group.No adverse reactions were found during or after treatment in both groups.Conclusion:Shenfu Injec-tion can effectively reduce the serum related inflammatory index,improve hemodynamics,improve cardiac function,improve the quality of life,and have a good effect.
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